NEW FAMILY OF LOW-MOLECULAR WEIGHT ANTIBIOTICS FROM ENTEROBACTERIA
NEW FAMILY OF LOW-MOLECULAR WEIGHT ANTIBIOTICS FROM ENTEROBACTERIA
复制标题
DOI：
10.1016/s0006-291x(76)80264-1
复制
发表时间：
1976-01-01
影响因子：
3.1
通讯作者：
BAQUERO, F
中科院分区：
文献类型：
--
作者：
ASENSIO, C;PEREZDIAZ, JC;BAQUERO, F
在从人类粪便中分离出的细菌培养基中检测到一个显然是新的抗生素家族。在初步研究中，对10种不同的化合物进行了部分纯化和表征。它们都是热稳定的，可溶于甲醇-水（5：1）中，分子量约为1000或更小，作为一系列肠杆菌以及其它非肠道微生物的生长抑制剂显示出不同程度的特异性。目前的工作强烈表明，在肠杆菌科和其他细菌家族中存在其他类似的化合物。
An apparently new family of antibiotics was detected in the culture media of bacteria isolated from human feces. In a preliminary investigation 10 different compounds were partially purified and characterized. All of them are thermostable, soluble in methanol-water (5:1) and have a MW of about 1000 or less. They show a different degree of specificity as growth inhibitors of a series of enterobacteria as well as other non-enteric microorganisms. Current work strongly suggests the existence of other similar compounds among Enterobacteriaceae and other bacterial families.