MULTIPLICATION OF A HUMAN PARASITE (LEISHMANIA-DONOVANI) IN PHAGOLYSOSOMES OF HAMSTER MACROPHAGES INVITRO
MULTIPLICATION OF A HUMAN PARASITE (LEISHMANIA-DONOVANI) IN PHAGOLYSOSOMES OF HAMSTER MACROPHAGES INVITRO
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DOI：
10.1126/science.948742
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发表时间：
1976-01-01
期刊：
影响因子：
56.9
通讯作者：
DWYER, DM
中科院分区：
文献类型：
--
作者：
CHANG, KP;DWYER, DM
用金黄地鼠腹腔巨噬细胞体外培养人内脏利什曼病病原体杜氏利什曼原虫。通过使用溶酶体标记的EM，可以看到这些寄生原虫在宿主细胞吞噬酶体内繁殖。这种细胞内寄生虫的存活机制显然是基于对巨噬细胞溶酶体酶消化的抵抗力。
L. donovani, the etiological agent of human visceral leishmaniasis, was grown in hamster peritoneal macrophages in vitro. By EM using a lysosomal marker, these parasitic protozoa were seen to multiply within host cell phagolysosomes. The survival mechanism of this intracellular parasite is based apparently upon resistance to macrophage lysosomal enzymatic digestion.