MotifSuite: workflow for probabilistic motif detection and assessment
MotifSuite: workflow for probabilistic motif detection and assessment
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DOI：
10.1093/bioinformatics/bts293
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发表时间：
2012-07-15
期刊：
影响因子：
5.8
通讯作者：
Marchal, Kathleen
中科院分区：
文献类型：
--
作者：
Claeys, Marleen;Storms, Valerie;Marchal, Kathleen
动机：概率基序检测需要一个多步骤的方法，从实际的从头开始的调控基序发现到对预测基序的繁琐评估。MotifSuite，一个用户友好的web界面简化了这个分析流程。它的核心包括两个后处理程序，允许优先顺序motif检测输出。MotifSuite提供的工具是围绕完善的motif检测工具MotifSampler构建的，也可以与任何其他概率motif检测工具结合使用。对每一种应用都提供了详细的指导方针。
Motivation: Probabilistic motif detection requires a multi-step approach going from the actual de novo regulatory motif finding up to a tedious assessment of the predicted motifs. MotifSuite, a user-friendly web interface streamlines this analysis flow. Its core consists of two post-processing procedures that allow prioritizing the motif detection output. The tools offered by MotifSuite are built around the well-established motif detection tool MotifSampler and can also be used in combination with any other probabilistic motif detection tool. Elaborate guidelines on each of its applications have been provided.