Etiology and Management of Male latrogenic Urethral Stricture: Retrospective Analysis of 172 Cases in a Single Medical Center
Etiology and Management of Male latrogenic Urethral Stricture: Retrospective Analysis of 172 Cases in a Single Medical Center
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DOI：
10.1159/000444592
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发表时间：
2016-01-01
影响因子：
1.6
通讯作者：
Lazzeri, Massimo
中科院分区：
文献类型：
--
作者：
Zhou, Shu-Kui;Zhang, Jiong;Lazzeri, Massimo
目的：探讨中国男性医源性尿道狭窄的病因及治疗方法。方法：回顾性分析2008年1月至2014年2月国内某大容量参考中心收治的172例医源性尿道狭窄患者的资料。通过对数据库的分析，了解不同类型医源性损伤对尿道狭窄的位置、长度、治疗及成功率的影响。结果：80例患者中，医源性狭窄最常见的类型是尿道器械，占46.51%。平均狭窄长度为3.3 +/- 2.54 cm，最长的狭窄为I型膀胱内灌注引起的狭窄。替代尿道成形术是最常见的干预措施，占60.47%（104/172）的患者。总成功率为85.00%（136/160）。单变量分析显示，医源性损伤类型与再狭窄显著相关（p = 0.036），且膀胱内灌注型较其他类型更容易发生术后再狭窄。结论：尿道内固定是医源性尿道狭窄最常见的病因，且大多数医源性尿道狭窄累及前尿道。不同的病因与尿道狭窄的位置、长度和整体预后密切相关。(C) 2016 S. Karger AG，巴塞尔
Purpose: To investigate the etiology and management of male iatrogenic urethral stricture in China. Methods: The data of 172 patients with iatrogenic urethral stricture who underwent treatment at a high volume reference center in China from January 2008 to February 2014 were analyzed retrospectively. Databases were analyzed to understand the impact of different types of iatrogenic injury on stricture location, length and treatment of urethral strictures, as well as success rates. Results: The most common type of iatrogenic stricture was urethral instrumentations in 80 patients (46.51%). Mean stricture length was 3.3 +/- 2.54 cm and the longest strictures were those caused by intravesica I instillation. Substitution urethroplasty was the most common intervention and was performed in 60.47% (104/172) of patients. The overall success rate was 85.00% (136/160). Univariable analyses revealed that the type of iatrogenic injury was significantly related to restenosis (p = 0.036), and it is more apt to postoperative restenosis in the type of intravesical instillation than others. Conclusion: Our results showed that urethral instrumentation is the most common etiology of iatrogenic urethral stricture, and most iatrogenic urethral strictures involve the anterior urethra. The different etiologies are closely associated with stricture location, length and the overall prognosis of urethral strictures. (C) 2016 S. Karger AG, Basel