Improvement of psoriasis of the scalp with ketoconazole.
Improvement of psoriasis of the scalp with ketoconazole.
复制标题
用酮康唑改善头皮牛皮癣。
DOI：
10.1001/archderm.1982.01650180004002
复制
发表时间：
1982
影响因子：
--
通讯作者：
P. Belew
中科院分区：
文献类型：
--
作者：
E. Rosenberg;P. Belew
-我们最近提出，牛皮癣通常是各种微生物产品与异常反应的替代补体途径相互作用的结果。1在我们提出的可能在银屑病中发挥作用的微生物产品中，有一种是卵形马拉色菌(Pityroporum Ovale)，它通常存在于头皮中，是替代补体途径的有效激活剂。最近酮康唑的上市为我们提供了一个检验我们假设的机会。如果卵形支气管炎确实引起了头皮银屑病的发展，那么只需口服酮康唑就可以成功地治疗头皮银屑病。酮康唑已被报道用于治疗两只狗的糠孢子菌毛囊炎、2只花斑癣、3只斑癣和P犬皮炎。外用硝酸益康唑，一种与咪唑相关的抗生素，据报道对治疗有效。
To the Editor.— We have recently proposed that psoriasis is ordinarily the result of the interaction of various microbial products with an abnormally responsive alternative complement pathway. 1 Among the microbial products we suggested might play a role in psoriasis was the yeast Malassezia ovalis (Pityrosporum ovale) , which is normally present in the scalp and is a potent activator of the alternative complement pathway. The recent availability of ketoconazole has provided us with an opportunity to test our hypothesis. If M ovalis were indeed evoking the development of psoriatic disease of the scalp, it should be possible to treat psoriasis of the scalp successfully with nothing but oral ketoconazole. Ketoconazole has been reported to be effective in the treatment of Pityrosporum folliculitis, 2 tinea versicolor, 3 and P canis -induced dermatitis in two dogs. 4 Topical econazole nitrate, a related imidazole antibiotic, was reported to be effective in the treatment