Gene expression profiling to identify genes associated with high-invasiveness in human squamous cell carcinoma with epithelial-to-mesenchymal transition
Gene expression profiling to identify genes associated with high-invasiveness in human squamous cell carcinoma with epithelial-to-mesenchymal transition
复制标题
DOI：
10.1016/j.canlet.2008.01.045
复制
发表时间：
2008-06-18
期刊：
影响因子：
9.7
通讯作者：
Kamata, Nobuyuki
中科院分区：
文献类型：
--
作者：
Higashikawa, Koichiro;Yoneda, Shingo;Kamata, Nobuyuki
上皮细胞向间质细胞转化（EMT）的过程涉及肿瘤获得高侵袭性。Snail抑制靶基因并诱导EMT。在这项研究中，我们定义了基因表达的cDNA微阵列分析在两个人鳞状细胞癌（SCC）细胞系自发EMT和蜗牛诱导EMT，表现出高侵袭性的行为在体外的签名。在17，000个cDNA探针中，发现61个基因的差异表达>2-或
The process of epithelial-to-mesenchymal transition (EMT) involves the acquisition of high-invasiveness by tumor. Snail represses target genes and induces EMT. In this study, we defined the signatures of gene expressions by cDNA microarray analyses in both human squamous cell carcinoma (SCC) cell lines with spontaneous EMT and with Snail-induced EMT, which exhibited high-invasive behavior in vitro. Of the 17,000 cDNA probes, 61 genes were found differentially expressed with >2- or