Development of hormonal control over food intake and body weight in female rats.
Development of hormonal control over food intake and body weight in female rats.
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雌性大鼠对食物摄入和体重的激素控制的发展。
DOI：
10.1037/h0028713
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发表时间：
1970
期刊：
影响因子：
--
通讯作者：
I. Zucker
中科院分区：
文献类型：
--
作者：
G. Wade;I. Zucker
发现在出生当天或断奶时切除卵巢对体重没有影响，直到青春期后，切除卵巢的雌性体重显着高于完整的对照组。苯甲酸雌二醇（EB）治疗没有减少食物摄入量或体重，直到Ss约40天。对雌激素的反应性的发作是独立的青春期。垂体切除术大大增加了青春期前SS对EB的反应。有人建议，青春期前的垂体分泌物消除腹内侧下丘脑（VMH）对食物摄入量的限制;由于雌激素作用于VMH抑制进食，这说明缺乏影响的食物消费在青春期前的时期，雌激素是无效的;有人建议，安非他明直接作用于外侧下丘脑，这是不难治性在青春期前的时期。(30参考文献）（PsycInfo数据库记录（c）2016阿帕，保留所有权利）
Found ovariectomy on the day of birth or at weaning to have no effect on body weight until after puberty when spayed females weighed significantly more than intact controls. Treatment with estradiol benzoate (EB) did not decrease food intake or body weight until Ss were approximately 40 days old. Onset of responsiveness to estrogens was independent of puberty. Hypophysectomy greatly increased responsiveness to EB among prepubertal Ss. It is suggested that prepubertal pituitary secretions eliminate ventromedial hypothalamic (VMH) restraint over food intake; since estrogens act on the VMH to depress eating, this accounts for the lack of effect of food consumption during prepubertal periods when estrogens were ineffective; it is suggested that amphetamine acts directly on the laternal hypothalamus which is not refractory during the prepubertal period.(30 ref.)(PsycINFO Database Record (c) 2016 APA, all rights reserved)