Fat in the intestine as a regulator of appetite - role of CCK
Fat in the intestine as a regulator of appetite - role of CCK
复制标题
DOI：
10.1016/j.physbeh.2004.07.031
复制
发表时间：
2004-12-30
影响因子：
2.9
通讯作者：
Degen, L
中科院分区：
文献类型：
--
作者：
Beglinger, C;Degen, L
本文综述了肠道脂肪在调节人类食物摄入中的食欲抑制作用，特别关注胆囊收缩素（CCK）的作用。目前的证据支持肠道脂肪（特别是长链游离脂肪酸）通过肽CCK作为生理饱腹感途径发挥作用。然而，饱腹感的调节是复杂的，存在多个控制系统并不奇怪。有趣的是，注意到营养物，如小肠中脂肪的水解产物，刺激饱腹感肽的释放，如CCK或PYY，其用作饱腹感信号。CCK通过消化食物的局部作用从胃肠道释放，发挥多种功能：刺激胆囊收缩和胰腺外分泌，抑制胃排空和抑制食欲。因此，CCK的作用是：（1）作为刺激消化过程的正反馈信号，（2）作为限制单餐食物消耗量的负反馈信号。(C)2004年爱思唯尔公司All rights reserved.
The present review summarizes the appetite-suppressing effects of intestinal fat in the regulation of food intake in humans, with a special focus on the role of cholecystokinin (CCK). Current evidence supports a role for intestinal fat (especially long-chain free fatty acids) acting via the peptide CCK as a physiological satiety pathway. The regulation of satiety is, however, complex and it is not surprising that multiple control systems exist. It is interesting to note that nutrients, such as hydrolysis products of fat in the small intestine, stimulate the release of satiety peptides, such as CCK or PYY, that serve as satiety signals. CCK, released from the gastrointestinal tract by the local action of digested food, exerts various functions: stimulation of gallbladder contraction and exocrine pancreatic secretion, inhibition of gastric emptying, and inhibition of appetite. CCK functions therefore (1) as a positive feedback signal to stimulate digestive processes and (2) as negative feedback signal to limit the amount of food consumed during an individual meal. (C) 2004 Elsevier Inc. All rights reserved.