Low non-oxidative glucose metabolism and violent offending: an 8-year prospective follow-up study.
Low non-oxidative glucose metabolism and violent offending: an 8-year prospective follow-up study.
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低非氧化葡萄糖代谢和暴力犯罪：一项为期 8 年的前瞻性随访研究。
DOI：
10.1016/j.psychres.2008.03.026
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发表时间：
2009
影响因子：
11.3
通讯作者：
Tiihonen,Jari
中科院分区：
文献类型：
--
作者：
Virkkunen,Matti;Rissanen,Aila;Franssila-Kallunki,Anja;Tiihonen,Jari
暴力犯罪者的葡萄糖代谢异常，表现为前额皮质的葡萄糖摄取减少和葡萄糖耐量测试中的低血糖最低点。我们测试了这样的假设：低非氧化葡萄糖代谢（NOG）预示着反社会男性即将发生的暴力犯罪。在法医精神病学检查期间，使用胰岛素钳夹法测量了 49 名冲动、暴力、反社会犯罪者的葡萄糖代谢。那些在 8 年随访期间至少犯下一项新暴力犯罪的罪犯的平均 NOG 比非累犯罪犯低 1.4 个标准差。在逻辑回归分析中，仅 NOG 就解释了累犯中 27% 的变异。低非氧化代谢可能是反社会人格障碍患者习惯性暴力行为病理生理学的重要组成部分。这可能表明增加糖原形成和降低低血糖风险的物质可能是冲动暴力行为的潜在治疗方法。
Violent offenders have abnormalities in their glucose metabolism as indicated by decreased glucose uptake in their prefrontal cortex and a low blood glucose nadir in the glucose tolerance test. We tested the hypothesis that low non-oxidative glucose metabolism (NOG) predicts forthcoming violent offending among antisocial males. Glucose metabolism was measured using the insulin clamp method among 49 impulsive, violent, antisocial offenders during a forensic psychiatric examination. Those offenders who committed at least one new violent crime during the 8-year follow-up had a mean NOG of 1.4 standard deviations lower than non-recidivistic offenders. In logistic regression analysis, NOG alone explained 27% of the variation in the recidivistic offending. Low non-oxidative metabolism may be a crucial component in the pathophysiology of habitually violent behavior among subjects with antisocial personality disorder. This might suggest that substances increasing glycogen formation and decreasing the risk of hypoglycemia might be potential treatments for impulsive violent behavior.