Relation of PvuII site polymorphism in the COL1A2 gene to the risk of fractures in prepubertal Finnish girls
Relation of PvuII site polymorphism in the COL1A2 gene to the risk of fractures in prepubertal Finnish girls
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DOI：
10.1152/physiolgenomics.00070.2003
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发表时间：
2003-08-15
影响因子：
4.6
通讯作者：
Cheng, SL
中科院分区：
文献类型：
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作者：
Suuriniemi, M;Mahonen, A;Cheng, SL
骨折的遗传易感性可能在儿童早期就可检测到。我们评估了244名青春期前芬兰女孩的COL 1A 2基因多态性PvuII位点与不同方式（双能X线吸收测定法;外周定量计算机断层扫描;凝胶耦合扫描定量超声测定法;超声骨超声测定法）评估的骨特性、骨转换标志物和骨折发生率之间的相关性。不同COL 1A 2基因型女孩的坦纳分期和体格特征无显著差异。当将坦纳I期（青春期前）和II期（青春期早期）的女孩放在一起考虑时，该多态性与不同的骨特性或任何骨转换标志物均无显著相关性，但与脊柱骨矿物质含量（BMC）和骨矿物质密度（BMD）以及声速（SOS）有显著相关性（P
Genetic susceptibility to fractures may be detectable in early childhood. We evaluated the associations between the polymorphic PvuII site of the COL1A2 gene and bone properties assessed by different modalities (dual-energy X-ray absorptiometry; peripheral quantitative computed tomography; gel coupling scanning quantitative ultrasonometry; ultrasound bone sonometry), bone turnover markers, and the occurrence of fractures in 244 prepubertal Finnish girls. Tanner stage and physical characteristics did not differ significantly among girls with different COL1A2 genotypes. The polymorphism was not significantly associated with different bone properties or any of the bone turnover markers when girls at Tanner stage I (prepuberty) and stage II (early puberty) were considered together, but there was a significant association with spine bone mineral content (BMC) and bone mineral density (BMD), as well as with speed of sound (SOS) (P