Getting to the Heart of the Matter: Age-related Changes in Diastolic Heart Function in the Longest-lived Rodent, the Naked Mole Rat
Getting to the Heart of the Matter: Age-related Changes in Diastolic Heart Function in the Longest-lived Rodent, the Naked Mole Rat
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DOI：
10.1093/gerona/glr222
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发表时间：
2012-04-01
影响因子：
5.1
通讯作者：
Buffenstein, Rochelle
中科院分区：
文献类型：
--
作者：
Grimes, Kelly M.;Lindsey, Merry L.;Buffenstein, Rochelle
裸鼹鼠是一种寿命极长（>31 年）的小型（35 克）啮齿动物。此外，它在其漫长一生的大部分时间里都保持着良好的健康状况。我们假设裸鼹鼠也表现出心脏衰老的减弱。随着年龄的增长，心肌的顺应性会降低，导致早期舒张期充盈下降 (E) 和心房收缩引起的晚期充盈 (A) 代偿性增加。这导致左心室 E/A 比值降低。多普勒成像显示，尽管雌激素水平存在差异，但老年（18-20 岁）饲养者和非饲养者的 E/A 比率（p = .48）没有显着差异。对 1 至 20 岁裸鼹鼠 (n = 76) 的横断面研究表明，雌性 (n = 40；p = .002) 的 E/A 比率随年龄增长而下降，但雄性 (n = 36；p = 0.45) 则不然。尽管如此，两种性别的发病率或死亡率都没有随着年龄的增长而增加。这些发现表明，尽管之前观察到心脏组织中存在高脂质过氧化，但核磁共振必须具有避免进展为致命心脏病的机制。
The naked mole rat is an extremely long-lived (>31 years) small (35 g) rodent. Moreover, it maintains good health for most of its long life. We hypothesized that naked mole rats also show attenuated cardiac aging. With age, cardiac muscle can become less compliant, causing a decline in early diastolic filling (E) and a compensatory increase in atrial contraction-induced late filling (A). This results in decreased left ventricular E/A ratio. Doppler imaging showed no significant differences in E/A ratios (p = .48) among old (18-20 years) breeders and nonbreeders despite differences in estrogen levels. A cross-sectional study of 1- to 20-year-old naked mole rats (n = 76) revealed that E/A ratios declined with age in females (n = 40; p = .002) but not in males (n = 36; p = 0.45). Despite this, neither gender shows increased morbidity or mortality with age. These findings suggest that, notwithstanding the previously observed high lipid peroxidation in heart tissue, NMRs must possess mechanisms to stave off progression to fatal cardiac disease.