BMI and Mortality in Patients With New-Onset Type 2 Diabetes: A Comparison With Age- and Sex-Matched Control Subjects From the General Population
BMI and Mortality in Patients With New-Onset Type 2 Diabetes: A Comparison With Age- and Sex-Matched Control Subjects From the General Population
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DOI：
10.2337/dc17-1309
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发表时间：
2018-03-01
期刊：
影响因子：
16.2
通讯作者：
Rosengren, Annika
中科院分区：
文献类型：
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作者：
Edqvist, Jon;Rawshani, Araz;Rosengren, Annika
研究设计和方法我们前瞻性地评估了糖尿病病程为40 kg/m(2)的2型糖尿病患者的短期和长期死亡率，这种情况在65岁的患者中表现得更为明显。结论我们的研究结果表明，在这一领域的其他研究中，明显的矛盾发现可能受到了反向因果关系的影响。与对照组相比，长期超重(BMI 25~30 kg/m(2))的2型糖尿病患者的额外死亡风险较低，而BMI和Gt；=40 kg/m(2)的患者的风险显著增加。
OBJECTIVEType 2 diabetes is strongly associated with obesity, but the mortality risk related to elevated body weight in people with type 2 diabetes compared with people without diabetes has not been established.RESEARCH DESIGN AND METHODSWe prospectively assessed short-and long-term mortality in people with type 2 diabetes with a recorded diabetes duration = 40 kg/m(2), that was more pronounced in patients < 65 years old.CONCLUSIONSOur findings suggest that the apparent paradoxical findings in other studies in this area may have been affected by reverse causality. Long-term, overweight (BMI 25 to < 30 kg/m(2)) patients with type 2 diabetes had low excess mortality risk compared with control subjects, whereas risk in those with BMI >= 40 kg/m(2) was substantially increased.