Synthesis of palau'amide and its diastereomers: confirmation of its stereostructure
Synthesis of palau'amide and its diastereomers: confirmation of its stereostructure
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DOI：
10.1016/j.tetlet.2009.10.059
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发表时间：
2009-12-30
影响因子：
1.8
通讯作者：
Suenaga, Kiyotake
中科院分区：
文献类型：
--
作者：
Sugiyama, Hirokazu;Watanabe, Atsushi;Suenaga, Kiyotake
合成了具有细胞毒性的环缩酚肽帕劳'amide的四种非对映异构体（1-4）。化合物1的1H-1 NMR谱与天然帕劳'酰胺的1H-1 NMR谱相同。这建立了帕劳'amide的完整立体结构。(C)2009爱思唯尔有限公司保留所有权利。
Four diastereomers of palau'amide (1-4), a cytoroxic cyclodepsipeptide, were synthesized. The H-1 NMR spectrum of 1 was identical to that of natural palau'amide. This established the complete stereostructure of palau'amide. (C) 2009 Elsevier Ltd. All rights reserved.