Proposed standard nomenclature for the α- and β-globin gene families
Proposed standard nomenclature for the α- and β-globin gene families
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DOI：
10.1266/ggs.81.367
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发表时间：
2006-10-01
影响因子：
1.1
通讯作者：
Yang, Ziheng
中科院分区：
文献类型：
--
作者：
Aguileta, Gabriela;Bielawski, Joseph P.;Yang, Ziheng
珠蛋白家族的基因和蛋白质已经是一个经常性的研究对象了几十年。这种兴趣产生了大量的知识。然而，由于缺乏系统的方法来命名基因，并且未能反映基因家族中基因之间的系统发育关系，因此它也产生了不一致和混乱的命名法。为了缓解现有系统的问题，在这里，我们提出了一个标准化的命名法的α和β珠蛋白家族的基因，脊椎动物α和β珠蛋白的系统发育分析的基础上，并遵循人类基因命名指南。
The globin family of genes and proteins has been a recurrent object of study for many decades. This interest has generated a vast amount of knowledge. However it has also created an inconsistent and confusing nomenclature, due to the lack of a systematic approach to naming genes and failure to reflect the phylogenetic relationships among genes of the gene family. To alleviate the problems with the existing system, here we propose a standardized nomenclature for the alpha and beta globin family of genes, based on a phylogenetic analysis of vertebrate alpha and beta globins, and following the Guidelines for Human Gene Nomenclature.