Genetic variation in Th1/Th2 pathway genes and risk of non-Hodgkin lymphoma: a pooled analysis of three population-based case-control studies.
Genetic variation in Th1/Th2 pathway genes and risk of non-Hodgkin lymphoma: a pooled analysis of three population-based case-control studies.
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DOI：
10.1111/j.1365-2141.2010.08424.x
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发表时间：
2011-05
影响因子：
6.5
通讯作者：
Rothman N
中科院分区：
文献类型：
--
作者：
Lan Q;Wang SS;Menashe I;Armstrong B;Zhang Y;Hartge P;Purdue MP;Holford TR;Morton LM;Kricker A;Cerhan JR;Grulich A;Cozen W;Zahm SH;Yeager M;Vajdic CM;Schenk M;Leaderer B;Yuenger J;Severson RK;Chatterjee N;Chanock SJ;Zheng T;Rothman N
Th1和Th2活性之间的平衡对淋巴样细胞的发育和分化至关重要。免疫功能障碍是淋巴瘤发生的基础，因此关键Th1/Th2细胞因子调节的改变可能导致非霍奇金淋巴瘤(NHL)的发生。为了研究Th1/Th2细胞因子基因多态性对非霍奇金淋巴瘤发病风险的影响，我们在3个基于人群的病例对照研究中，分析了17个Th1/Th2细胞因子及相关基因145个标签单核苷酸多态性(SNPs)。用Logistic回归分析计算非霍奇金淋巴瘤及其4种主要亚型与Tag SNP和单倍型的比值比(OR)。一项基于基因的分析调整了每个基因中标签SNPs的数量，结果显示，与合并NHL的风险以及Th1(IL12A和IL12RB1)和Th2(IL4、IL10RB和IL18)基因的一个或多个NHL亚型显著相关。其中IL12A rs485497的关联性最强，它在先天抵抗和抗原特异性获得性免疫反应的细胞和体液途径之间起着中心作用(等位基因风险OR=1.17；P(趋势)=0.00099)。该单核苷酸多态与滤泡性淋巴瘤的发病风险相关(等位基因风险OR=1.2 6；P(趋势)=0.0012)。这些发现提示Th1/Th2细胞因子基因的遗传变异可能与淋巴肿大有关。
The balance between Th1 and Th2 activity is critical in lymphoid cell development and differentiation. Immune dysfunction underlies lymphomagenesis, so an alteration in the regulation of key Th1/Th2 cytokines may lead to the development of non-Hodgkin lymphoma (NHL). To study the impact of polymorphism in Th1/Th2 cytokines on NHL risk, we analyzed 145 tag single nucleotide polymorphisms (SNPs) in 17 Th1/Th2 cytokine and related genes in three population-based case-control studies (1,946 cases and 1,808 controls). Logistic regression was used to compute odds ratios (OR) for NHL and four major NHL subtypes in relation to tag SNP genotypes and haplotypes. A gene-based analysis adjusting for the number of tag SNPs genotyped in each gene showed significant associations with risk of NHL combined and one or more NHL subtypes for Th1 (IL12A and IL12RB1) and Th2 (IL4, IL10RB, and IL18) genes. The strongest association was for IL12A rs485497, which plays a central role in bridging the cellular and humoral pathways of innate resistance and antigen-specific adaptive immune responses (allele risk OR=1.17; P(trend)=0.00099). This SNP was also associated specifically with risk of follicular lymphoma (allele risk OR=1.26; P(trend)=0.0012). These findings suggest that genetic variation in Th1/Th2 cytokine genes may contribute to lymphomagenesis.
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影响因子：
2.9
作者：
Murtaugh, Michael P.;Johnson, Craig R.;Zhou, Yaling
通讯作者：
Zhou, Yaling
DOI：
10.1084/jem.20021769
发表时间：
2003-02-17
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Fieschi C;Dupuis S;Catherinot E;Feinberg J;Bustamante J;Breiman A;Altare F;Baretto R;Le Deist F;Kayal S;Koch H;Richter D;Brezina M;Aksu G;Wood P;Al-Jumaah S;Raspall M;Da Silva Duarte AJ;Tuerlinckx D;Virelizier JL;Fischer A;Enright A;Bernhöft J;Cleary AM;Vermylen C;Rodriguez-Gallego C;Davies G;Blütters-Sawatzki R;Siegrist CA;Ehlayel MS;Novelli V;Haas WH;Levy J;Freihorst J;Al-Hajjar S;Nadal D;De Moraes Vasconcelos D;Jeppsson O;Kutukculer N;Frecerova K;Caragol I;Lammas D;Kumararatne DS;Abel L;Casanova JL
通讯作者：
Casanova JL
影响因子：
3.8
作者：
Palmieri, Rachel T.;Wilson, Melanie A.;Schildkraut, Joellen M.
通讯作者：
Schildkraut, Joellen M.
影响因子：
20.3
作者：
Lan, Qing;Zheng, Tongzhang;Chanock, Stephen
通讯作者：
Chanock, Stephen
影响因子：
3.1
作者：
Liu, Yunguang;Lin, Na;Pang, Guangfu
通讯作者：
Pang, Guangfu