Asynchrony of quantal events in evoked multiquantal responses indicates presynaptic quantal interaction.
Asynchrony of quantal events in evoked multiquantal responses indicates presynaptic quantal interaction.
复制标题
诱发多量子反应中量子事件的异步表明突触前量子相互作用。
DOI：
10.1152/jn.1999.81.5.2234
复制
发表时间：
1999
影响因子：
2.5
通讯作者：
Worden,MK
中科院分区：
文献类型：
--
作者：
Bykhovskaia,M;Hackett,JT;Worden,MK
Asynchrony of quantal events in evoked multiquantal responses indicates presynaptic quantal interaction. We have analyzed the possibility of quantal interactions by inspecting action potential-evoked postsynaptic multiquantal responses recorded extracellularly from the lobster neuromuscular junction. These recorded responses were compared with simulated multiquantal responses constructed from statistically independent quantal events. The simulated multiquantal responses were generated by random superposition of single quantal responses aligned according to the timing of the action potential. The methods of analysis consisted of1) the comparison of quantal contents obtained from direct counting or by measuring of the size of the responses and2) the analysis of distributions of quantal latencies. This analysis revealed a large error in the detection of quantal events for responses simulated with no quantal interaction. In contrast, very few errors in quantal detection were made in the analysis of experimental recordings. Latency histograms of recorded responses demonstrate that the proportion of late quantal events (those with latencies of ≥5 ms) increased as a function of quantal content. This shift in latency histograms was not observed for simulated responses. Our interpretation is that quanta interact presynaptically to cause asynchrony of quantal events in evoked responses.
