Prenatal alcohol exposure predicts continued deficits in offspring size at 14 years of age.
Prenatal alcohol exposure predicts continued deficits in offspring size at 14 years of age.
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DOI：
10.1111/j.1530-0277.2002.tb02459.x
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发表时间：
2002-10
期刊：
影响因子：
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通讯作者：
N. Day;S. Leech;G. Richardson;M. Cornelius;N. Robles;Cynthia A. Larkby
中科院分区：
文献类型：
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作者：
N. Day;S. Leech;G. Richardson;M. Cornelius;N. Robles;Cynthia A. Larkby
背景生长缺陷是诊断胎儿酒精综合征的主要特征之一。在产前接触酒精但没有胎儿酒精综合征的人中也注意到生长缺陷。然而，很少有研究观察过儿童早期和中期的受试者，以评估产前酒精暴露对青春期生长的长期影响。这是一份关于妊娠期酒精暴露对14岁后代大小影响的报告。方法妇女在她们的产前第四个月被招募。这些妇女在怀孕的第四个月和第七个月以及分娩时接受了采访。这些妇女和她们的孩子在孩子14岁时被看到。结果在14岁的后代中发现了与产前酒精暴露相关的生长缺陷。体重，身高，头围，皮褶厚度继续显着影响产前酒精暴露后，控制其他显着的预测因素的大小。这些影响表现出剂量-反应模式，并且在每天低于一杯的水平下发现了显著的影响。例如，妊娠前三个月的酒精暴露预测戒酒者的后代体重为152磅，轻度饮酒者的后代体重为149磅（每天饮酒量>0和0.2和0.89）。结论：产前酒精暴露继续影响14岁以下的儿童的大小，从他们怀孕的第四个月开始。
BACKGROUND Growth deficits are among the cardinal features for the diagnosis of fetal alcohol syndrome. Growth deficits have also been noted among those who were exposed to alcohol prenatally but who do not have fetal alcohol syndrome. Few studies have observed subjects past early and middle childhood, however, to evaluate the longer-term effects of prenatal alcohol exposure on growth in adolescence. This is a report of the effects of alcohol exposure during gestation on the size of the offspring at 14 years of age. METHODS Women were recruited in their fourth prenatal month. These women were interviewed in the fourth and seventh months of pregnancy and at delivery. The women and their children were seen when the offspring were 14 years of age. RESULTS Growth deficits associated with prenatal alcohol exposure were identified among the offspring at 14 years of age. Weight, height, head circumference, and skinfold thickness continued to be significantly affected by prenatal alcohol exposure after controlling for other significant predictors of size. These effects exhibited a dose-response pattern, and significant effects were found at levels below one drink per day. For example, first trimester alcohol exposure predicted weights of 152 lbs for the offspring of abstainers, 149 lbs for the offspring of light drinkers (>0 and 0.2 and 0.89 drinks per day). CONCLUSIONS Prenatal alcohol exposure continues to affect size at age 14 years in this cohort of children followed since their fourth month of gestation.