A Novel, Broad-Spectrum Antimicrobial Combination for the Treatment of Pseudomonas aeruginosa Corneal Infections
A Novel, Broad-Spectrum Antimicrobial Combination for the Treatment of Pseudomonas aeruginosa Corneal Infections
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DOI：
10.1128/aac.00777-19
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发表时间：
2019-10-01
影响因子：
4.9
通讯作者：
Wozniak, Rachel A. F.
中科院分区：
文献类型：
--
作者：
Chojnacki, Michaelle;Philbrick, Alesa;Wozniak, Rachel A. F.
细菌性角膜炎导致严重的失明，但抗生素耐药性使目前的治疗无效。多粘菌素B-甲氧苄啶（PT）加利福平对金黄色葡萄球菌和铜绿假单胞菌（两种重要的角膜炎病因）具有有效的体外活性。在此，我们进一步在鼠角膜炎模型中表征该组合对铜绿假单胞菌的作用。PT加利福平的疗效与金标准氟沙星相当或更好，表明联合用药可能是治疗细菌性角膜炎的一种有前景的方法。
Bacterial keratitis causes significant blindness, yet antimicrobial resistance has rendered current treatments ineffective. Polymyxin B-trimethoprim (PT) plus rifampin has potent in vitro activity against Staphylococcus aureus and Pseudomonas aeruginosa, two important causes of keratitis. Here we further characterize this combination against P. aeruginosa in a murine keratitis model. PT plus rifampin performed comparably to or better than moxifloxacin, the gold standard, suggesting that the combination may be a promising therapy for bacterial keratitis.