Molecular Imaging, Oncology, and the Arc toward Our Precision Future.
Molecular Imaging, Oncology, and the Arc toward Our Precision Future.
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分子成像、肿瘤学和通往精准未来的弧线。
DOI：
10.1148/radiol.231930
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发表时间：
2023
期刊：
影响因子：
19.7
通讯作者：
Mahmood,Umar
中科院分区：
文献类型：
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作者：
Mahmood,Umar
并测量其对治疗的反应。与血液检查不同，血液检查通常不提供关于这些异常发生的信息，分子成像提供了对所有转移部位的特定靶点异常水平的评估。此外，在个体患者的肿瘤病灶中经常观察到异质性，随着时间的推移，治疗药物的选择压力使其变得更加复杂。积累突变使施用的药物不那么有效的癌细胞更有可能存活。分子成像可以了解表达在不同肿瘤部位和随时间的变化。这使得更有效的治疗，组合，并在成像显示可能发生治疗失败的部位时早期改变方案。在未来几年，我们将看到在治疗开始前对组织样本进行先进的基因组分析，结合癌症治疗前和治疗期间进行的分子成像和血清检测。
abnormalities and measure their response to treatment. Unlike blood tests, which do not generally provide information on where these abnormalities are occurring, molecular imaging provides an assessment of the level of a specific target abnormality across all metastatic sites. Moreover, heterogeneity is often seen across tumor foci within individual patients, which is compounded over time by the selection pressure of therapeutics. Cancer cells that accumulate mutations that render an administered drug less effective are more likely to survive. Molecular imaging allows an understanding of how expression varies both at different tumor sites and over time. This enables more effective treatments, combinations, and early changes to regimens when imaging suggests sites of therapy failure are likely to occur. In the coming years, we will see a growing intertwining of advanced genomic analysis of tissue samples before treatment starts, combined with molecular imaging and serum testing performed before and during cancer treatment.