Outbreak of Escherichia coli O157: H7 associated with raw milk consumption in the Pacific Northwest
Outbreak of Escherichia coli O157: H7 associated with raw milk consumption in the Pacific Northwest
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DOI：
10.1089/fpd.2007.0072
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发表时间：
2008-06-01
影响因子：
2.8
通讯作者：
Eckmann, K.
中科院分区：
文献类型：
--
作者：
Denny, Justin;Bhat, Maya;Eckmann, K.
2005年晚些时候，华盛顿克拉克县的卫生官员注意到居民中大肠杆菌病例的数量高于预期，并试图确定一个可能的共同感染源。为了确定风险因素，卫生官员进行了一项回顾性队列研究和一项使用脉冲场凝胶电泳（PFGE）的环境现场调查，以确定和预防未来病例的发生。几条证据支持生奶是感染的原因：1）所有患病者都饮用同一奶牛群的生奶; 2）患病与牛奶消费量的增加有关; 3）E。大肠杆菌O 157：H7分离自原料奶样品和挤奶厅地板上采集的环境样品; 4）PFGE图谱在病例-患者、原料奶样品和环境样品之间难以区分。总之，这些发现清楚地表明了与食用生奶相关的健康风险。媒体对这一调查的高度兴趣使公共卫生官员能够与州立法者合作，通过华盛顿州的州参议院第6377号法案，该法案澄清了州许可证要求适用于所有牛奶生产设施，包括奶牛共享计划。
In late 2005, health officials in Clark County, Washington noted a higher than expected number of Escherichia coli cases among residents and sought to identify a possible common source for infection. In order to identify risk factors, health officials conducted a retrospective cohort study and an environmental site investigation using pulsed-field gel electrophoresis (PFGE) to identify and prevent future cases from occurring. Several lines of evidence supported raw milk as the cause of infections: 1) all ill persons drank raw milk from the same cow share; 2) illness was associated with an increasing amount of milk consumed; 3) E. coli O157:H7 was isolated from raw milk samples and environmental samples collected from the floor of the milking, parlour; and 4) PFGE patterns were indistinguishable between case-patients, raw milk samples, and environmental samples. Together, these findings made clear the health risks associated with the consumption of raw milk. The high amount of media interest in this investigation empowered public health officials to work, with state legislators to pass State Senate Bill 6377 in Washington State which clarified that state licensing requirements apply to all milk production facilities including cow-share programs.