Mouse white adipose tissue‐derived mesenchymal stem cells gain pericentral and periportal hepatocyte features after differentiation in vitro, which are preserved in vivo after hepatic transplantation
Mouse white adipose tissue‐derived mesenchymal stem cells gain pericentral and periportal hepatocyte features after differentiation in vitro, which are preserved in vivo after hepatic transplantation
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DOI：
10.1111/apha.12560
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发表时间：
2015-10
影响因子：
6.3
通讯作者：
Sandra Winkler;M. Hempel;S. Brückner;Franziska Mallek;A. Weise;T. Liehr;H. Tautenhahn;Michael Bartels;B. Christ
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文献类型：
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作者：
Sandra Winkler;M. Hempel;S. Brückner;Franziska Mallek;A. Weise;T. Liehr;H. Tautenhahn;Michael Bartels;B. Christ
间充质干细胞在体内外均可分化为肝细胞样细胞。因此，它们被认为是治疗各种肝脏疾病的新细胞资源。在这里，目的是证明间充质干细胞可以在体外和体内采用静脉周围和门静脉周围肝细胞特异性功能。
Mesenchymal stem cells may differentiate into hepatocyte‐like cells in vitro and in vivo. Therefore, they are considered a novel cell resource for the treatment of various liver diseases. Here, the aim was to demonstrate that mesenchymal stem cells may adopt both perivenous and periportal hepatocyte‐specific functions in vitro and in vivo.