High Affinity to Skeleton Rare Earth Doped Nanoparticles for Near-Infrared II Imaging
High Affinity to Skeleton Rare Earth Doped Nanoparticles for Near-Infrared II Imaging
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用于近红外 II 成像的骨架稀土掺杂纳米颗粒的高亲和力
DOI：
10.1021/acs.nanolett.9b00140
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发表时间：
2019-05-01
期刊：
影响因子：
10.8
通讯作者：
Cheng, Zhen
中科院分区：
文献类型：
--
作者：
He, Shuqing;Chen, Si;Cheng, Zhen
作为一种新的非侵入性的新兴模式，近红外-II荧光成像（1000-1700 nm）具有许多优势，比传统的可见光和近红外-I成像（700-900 nm）。不幸的是，只有少数NIR-II荧光团适合骨成像。在这里，我们报告了一种基于DSPE-mPEG封装的稀土掺杂纳米颗粒（RENPs@DSPE-mPEG）的NIR-II荧光团，它显示出与骨的固有亲和力，而不连接任何靶向配体，因此，它为骨骼系统绘图和骨骼疾病诊断提供了一种替代的非侵入性和非辐射策略。有趣的是，在NIR-II窗口内，在较长波长（1345 nm）下成像提供比在1064 nm下成像更高的分辨率和信噪比，即使在1064 nm下的量子产率比在1345 nm下的量子产率高2倍。除骨成像外，RENP 5 @DSPE-mPEG还显示了在血管和淋巴结中的成像应用。重要的是，RENP @DSPE-mPEG可以通过循环的白色血液内化，增加免疫治疗等领域的纳米颗粒有效递送，并提高癌症靶向纳米颗粒在临床应用中的诊断和治疗功效。
As a newly noninvasive emerging modality, NIR-II fluorescence imaging (1000-1700 nm) has many advantages over conventional visible and NIR-I imaging (700-900 nm). Unfortunately, only a few NIR-II fluorophores are suitable for bone imaging. Here, we report an NIR-II fluorophore based on DSPE-mPEG encapsulated rare earth doped nanoparticles (RENPs@DSPE-mPEG), which shows inherent affinity to bone without linking any targeting ligands, and thus, it provides an alternative noninvasive and nonradiation strategy for skeletal system mapping and bone disease diagnoses. Interestingly, within the NIR-II window, imaging at a longer wavelength (1345 nm) provides a higher resolution and signal-to-noise ratio than imaging at 1064 nm, even though the quantum yield at 1064 nm is 2-fold higher than that at 1345 nm. Besides bone imaging, RENP5@DSPE-mPEG show an imaging application in blood vessels and lymph nodes. Importantly, RENPs@DSPE-mPEG can be internalized by circulating white blood increase efficient nanoparticle delivery in the fields such as immunotherapy and improve the diagnostic and therapeutic efficacy of cancer-targeted nanoparticles in clinical applications.