EPIDERMAL GROWTH FACTOR AND RELATED MOLECULES
EPIDERMAL GROWTH FACTOR AND RELATED MOLECULES
复制标题
表皮生长因子及相关分子
DOI：
10.1016/s0140-6736(89)92339-8
复制
发表时间：
1989
期刊：
影响因子：
--
通讯作者：
M. Waterfield
中科院分区：
文献类型：
--
作者：
M. Waterfield
表皮生长因子（EGF）的发现以及随后对其生理作用和作用机制的研究，具有一个奇妙但未完成的侦探故事的所有特征。故事开始于20世纪60年代初，在维克托汉堡的实验室里，丽塔·列维-蒙塔尔奇尼和斯坦利·科恩正在寻找支持神经细胞发育和生长的因素。作为这项研究的一部分，用含有磷酸二酯酶的蛇毒处理肿瘤细胞提取物，以排除核酸的参与令人惊讶的是，蛇毒本身被发现具有神经生长因子样活性。
THE discovery of epidermal growth factor (EGF) and the subsequent search for its physiological role and mechanism of action have all the hallmarks of a marvellous but unfinished detective story. The tale begins in the early 1960s in the laboratory of Victor Hamburger, where Rita Levi-Montalcini and Stanley Cohen were looking for factors that supported nerve cell development and growth.! As part of this study, tumour cell extracts were treated with snake venom containing phosphodiesterases to rule out the participation of nucleic acids-surprisingly, the venom itself was found to have a nerve-growth-factor-like activity.
影响因子：
56.9
作者：
SLAMON, DJ;GODOLPHIN, W;PRESS, MF
通讯作者：
PRESS, MF