Identification of pyramidal cells as the critical elements in hippocampal neuronal plasticity during learning.
Identification of pyramidal cells as the critical elements in hippocampal neuronal plasticity during learning.
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鉴定锥体细胞是学习过程中海马神经元可塑性的关键元素。
DOI：
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发表时间：
1978
影响因子：
11.1
通讯作者：
R. Thompson
中科院分区：
文献类型：
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作者：
T. Berger;R. Thompson
研究了经典条件反射条件反射过程中记录的家兔海马单个神经元的活动。所有细胞首先根据它们在穹窿刺激后的反应进行分类-i.i.，逆向激活、顺向激活或不激活。大多数细胞，逆向激活-锥体细胞-显示出高度正相关的模式之间的单位放电和地形的nicititating膜反应在审判期间。单位，由穹窿刺激的顺向驱动往往抑制在审判刺激的演示文稿，而大多数非活化细胞在任何时候都保持低水平的自发活动。因此，海马的主要输出神经元似乎是这种经典条件反射范式诱导的大而快速发展的神经元可塑性的神经解剖学基质。
The activity of single neurons recorded from rabbit hippocampus during classical conditioning of the nictitating membrane reflex was studied. All cells were first categorized according to their responses after fornix stimulation--i.i., antidromic activation, orthodromic activation, or no activation. The majority of cells that were antidromically activated--pyramidal cells--showed a highly positive correlation between the pattern of unit discharge and the topography of the nicititating membrane response within trial periods. Units that were orthodromically driven by fornix stimulation tended to inhibit during the presentation of trial stimuli, whereas most non-activated cells maintained low spontaneous levels of activity at all times. Thus, the major output neurons of the hippocampus appear to be the neuroanatomical substrate for the large and rapidly developing neuronal plasticity induced by this classical conditioning paradigm.