Cell biology of vascular hypertrophy in systemic hypertension.
Cell biology of vascular hypertrophy in systemic hypertension.
复制标题
系统性高血压血管肥大的细胞生物学。
DOI：
10.1016/0002-9149(88)90029-x
复制
发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Gibbons,GH
中科院分区：
文献类型：
--
作者：
Dzau,VJ;Gibbons,GH
最近的数据表明，除了其导管功能之外，血管是一种活性合成和分泌器官，其含有几种参与其自身功能的局部调节的自分泌和旁分泌系统（即，结构和增长）。内皮分泌血管舒张和血管收缩物质、生长因子和炎症介质，对血管肌细胞功能产生旁分泌影响。血管肌细胞也表达影响其自身功能的自分泌物质。自分泌系统包括血管紧张素、肾上腺素、血小板衍生生长因子、胰岛素样生长因子和肝素。这些局部因素对肌细胞的收缩性和生长产生调节作用。这些自分泌和旁分泌系统作为一种适应机制，通过这种机制，脉管系统自动调节其结构和功能状态。我们推测，在这种微妙的平衡，这些局部因素的改变，由于遗传或获得性异常，可导致血管张力增加和血管肥大，从而有助于高血压的发病机制。
Recent data demonstrate that in addition to its conduit function, the blood vessel is an active synthetic and secretory organ containing several autocrine and paracrine systems that are involved with the local regulation of its own function (i.e., structure and growth). The endothelium secretes vasorelaxant and vasoconstrictive substances, growth factors and inflammatory mediators that exert paracrine influences on vascular myocyte function. The vascular myocyte also expresses autocrine substances that influence its own function. The autocrine systems include angiotensin, prostaglandins, platelet-derived growth factor, insulin-like growth factor and heparin. These local factors exert modulatory influences on myocyte contractility and growth. These autocrine and paracrine systems serve as an adaptive mechanism by which the vasculature autoregulates its structural and functional state. We speculate that an alteration in this delicate balance of these local factors, due to genetic or acquired abnormalities, can result in increased vascular tone and vessel hypertrophy and thereby contribute to the pathogenesis of hypertension.