Reference values of hematology, biochemistry, and blood type in cynomolgus monkeys from cambodia origin.
Reference values of hematology, biochemistry, and blood type in cynomolgus monkeys from cambodia origin.
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DOI：
10.5625/lar.2016.32.1.46
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发表时间：
2016-03
影响因子：
2.9
通讯作者：
Park W
中科院分区：
文献类型：
--
作者：
Choi K;Chang J;Lee MJ;Wang S;In K;Galano-Tan WC;Jun S;Cho K;Hwang YH;Kim SJ;Park W
食蟹猴作为非人灵长类动物，具有高度的人类基因同源性，是有价值的动物模型。食蟹猴血液学和生化指标对临床诊断和开展生物医学研究具有重要的参考价值。体重信息和血型也是同种异体或异种异体模型成功的关键因素。此外，食蟹猴的生物学参数可能因其来源而异。但是，提供的参考资料有限，特别是来自柬埔寨的资料。在这项研究中，我们测量了2518只食蟹猴的平均体重，分析了119只雄性食蟹猴的血液学和血清生化，并确定了642只柬埔寨血统的食蟹猴的血型。2 ~ 3岁雄性食蟹猴平均体重为2.56±0.345 kg，雌性食蟹猴平均体重为2.43±0.330 kg。与女性相比，男性组在3至4岁期间的平均体重相对急剧增加。在血液学和生物化学方面，虽然有一些结果存在差异，但与其他文献相比，大部分数据是相似的。ABO血型结果显示，A型、B型、AB型和O型分别约占15.6%、33.3%、44.2和6.9%。该机构的主要血型为B型和AB型。这些柬埔寨血统的生物背景参考可用于为在生物医学研究中使用它们的研究人员提供重要信息。
Cynomolgus monkeys as nonhuman primates are valuable animal models because they have a high level of human gene homology. There are many reference values for hematology and biochemistry of Cynomolgus monkeys that are needed for proper clinical diagnosis and biomedical research conduct. The body weight information and blood type are also key success factors in allogeneic or xenogeneic models. Moreover, the biological parameters could be different according to the origin of the Cynomolgus monkey. However, there are limited references provided, especially of Cambodia origin. In this study, we measured average body weight of 2,518 Cynomolgus monkeys and analyzed hematology and serum biochemistry using 119 males, and determined blood types in 642 monkeys with Cambodia origin. The average body weight of male Cynomolgus monkeys were 2.56±0.345 kg and female group was 2.43±0.330 kg at the age from 2 to 3 years. The male group showed relatively sharp increased average body weight from the 3 to 4 age period compared to the female group. In hematology and biochemistry, it was found that most of the data was similar when compared to other references even though some results showed differences. The ABO blood type result showed that type A, B, AB, and O was approximately 15.6, 33.3, 44.2, and 6.9%, respectively. The main blood type in this facility was B and AB. These biological background references of Cambodia origin could be used to provide important information to researchers who are using them in their biomedical research.