Synthesis of Collagenase-Sensitive Polyureas for Ligament Tissue Engineering
Synthesis of Collagenase-Sensitive Polyureas for Ligament Tissue Engineering
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DOI：
10.1002/mabi.201100063
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发表时间：
2011-08-11
影响因子：
4.6
通讯作者：
Cosgriff-Hernandez, Elizabeth
中科院分区：
文献类型：
--
作者：
Benhardt, Hugh;Sears, Nick;Cosgriff-Hernandez, Elizabeth
Recently, poly(ester urethanes) were investigated for use as ligament grafts due to their exceptional mechanical properties and highly tunable structure; however, these grafts are susceptible to hydrolytic degradation that occurs independent of tissue regeneration. To address this limitation, polyureas containing collagen-derived peptides were synthesized which enable cellular release of proteases to dictate degradation rate. It is hypothesized that this cell-responsive design will facilitate load transfer from the biodegradable scaffold to neotissue at a rate that promotes proper tissue orientation and function while maintaining construct integrity.
