St John's wort versus placebo in obsessive-compulsive disorder: results from a double-blind study.
St John's wort versus placebo in obsessive-compulsive disorder: results from a double-blind study.
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圣约翰草与安慰剂治疗强迫症：双盲研究的结果。
DOI：
10.1097/00004850-200511000-00003
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发表时间：
2005
影响因子：
2.6
通讯作者：
Vapnik,Tanya
中科院分区：
文献类型：
--
作者：
Kobak,KennethA;Taylor,LeslieVH;Bystritsky,Alexander;Kohlenberg,CaryJ;Greist,JohnH;Tucker,Phebe;Warner,Gemma;Futterer,Rise;Vapnik,Tanya
尽管圣约翰草（贯叶连翘）是最广泛使用和研究的治疗抑郁症的草药之一，但人们对其对焦虑症的功效知之甚少，尽管焦虑症患者是最有可能使用替代疗法进行自我治疗的患者之一。金丝桃的血清素能、多胺能和 GABA 胺能活性的药代动力学证据以及最近成功的开放标签研究表明，它可能对强迫症 (OCD) 有效。 60 名受试者被随机接受为期 12 周的圣约翰草 (LI 160) 或匹配的安慰剂治疗。汉密尔顿抑郁量表得分为 16 或以上的受试者被排除。采用灵活的剂量方案（600-1800 毫克/天）。圣约翰草组的耶鲁-布朗强迫量表 (Y-BOCS) 平均变化 (3.43) 与安慰剂组的平均变化 (3.60) 没有显着差异 (P= 899)。在任何 Y-BOCS 分量表上均未发现显着差异。在终点时被评为“很多”或“非常”改善的患者百分比在圣约翰草 (17.9%) 和安慰剂 (16.7%) 之间没有显着差异 (P= 0.905)。每组中只有一名患者因不良事件[鼻窦感染（圣约翰草）；混乱（安慰剂）]。结果未能支持圣约翰草对强迫症的功效。
Although St John's wort (Hypericum perforatum) is one of the most widely used and studied herbal medicines for depression, less is known about its efficacy in anxiety disorders, in spite of the fact that patients with anxiety disorders are among the most likely to self-medicate using alternative treatments. Pharmacokinetic evidence for the serotonergic, domaminergic and GABAminergic activity of hypericum, and a recent successful open-label study, suggests that it may be effective for obsessive–compulsive disorder (OCD). Sixty subjects were randomized to 12 weeks of treatment with St John's wort (LI 160) or matching placebo. Subjects with Hamilton Depression Scale scores of 16 or above were excluded. A flexible-dose schedule was utilized (600–1800 mg/day). The mean change on the Yale–Brown Obsessive–Compulsive Scale (Y-BOCS) with St John's wort (3.43) was not significantly different than the mean change found with placebo (3.60)(P= 899). No significant differences were found on any of the Y-BOCS subscales. The percentage of patients rated as ‘much’or ‘very much’improved at endpoint was not significantly different between St John's wort (17.9%) and placebo (16.7%)(P= 0.905). Only one patient from each group discontinued due to adverse events [sinus infection (St John's wort); confusion (placebo)]. The results fail to support the efficacy of St John's wort for OCD.