Overlapping auditory M100 and M200 abnormalities in schizophrenia and bipolar disorder: A MEG study
Overlapping auditory M100 and M200 abnormalities in schizophrenia and bipolar disorder: A MEG study
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精神分裂症和双相情感障碍中重叠的听觉 M100 和 M200 异常：一项 MEG 研究
DOI：
10.1016/j.schres.2014.10.042
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发表时间：
2014-12-01
影响因子：
4.5
通讯作者：
Huang, Li
中科院分区：
文献类型：
--
作者：
Wang, Ying;Jia, Yanbin;Huang, Li
目的：精神分裂症和双相情感障碍具有共同的病因和病理生理途径，并具有重叠的临床特征。只有少数研究直接比较了这两种疾病的早期听觉信息处理。本研究旨在探讨精神分裂症和双相情感障碍患者M100和M200听觉反应的脑磁图（MEG）特征，并与健康对照组进行比较。结果：所有受试者的M100和M200双极源均位于颞上级回（STG）的左右后部。正常对照组M100和M200听觉反应的不对称模式，在右侧STG中观察到更多的前源。然而，精神分裂症和双相情感障碍患者都表现出对称的M100和M200源模式。当与健康对照组相比，两个患者组表现出显着减少M100和M200源强度在两个hemisales.Conclusions：我们的研究表明，早期听觉信息处理缺陷可能是类似的精神分裂症和双相情感障碍，并可能与异常的STG。(C)2014由Elsevier B.V.出版
Objectives: Schizophrenia and bipolar disorder share common etiological factors and pathophysiological pathways and have overlapping clinical features. Only few studies have directly compared early auditory information processing in the two disorders. The objective of this study was to investigate the M100 and M200 auditory responses in patients with schizophrenia and bipolar disorder and compare them with healthy controls using magnetoencephalography (MEG).Methods: Whole-head MEG data were acquired during an auditory oddball paradigm in 24 schizophrenia patients, 26 bipolar I disorder patients, and 31 healthy controls. The strengths and latencies of M100 and M200 in both hemispheres and the dipole source localizations were investigated from the standard stimuli.Results: The M100 and M200 dipolar sources were localized to the left and right posterior portion of the superior temporal gyrus (STG) in all the subjects. An asymmetric pattern of M100 and M200 auditory response with more anterior sources in the right STG was observed in the healthy controls. However, both the schizophrenia and bipolar disorder patients showed a symmetric M100 and M200 source pattern. When compared with the healthy control group, both patient groups showed significantly reduced M100 and M200 source strength in both hemispheres.Conclusions: Our study suggests that early auditory information processing deficits may be similar in schizophrenia and bipolar disorder and may be related to abnormalities of the STG. (C) 2014 Published by Elsevier B.V.