Serotonin transporter polymorphism related to amygdala excitability and symptom severity in patients with social phobia
Serotonin transporter polymorphism related to amygdala excitability and symptom severity in patients with social phobia
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DOI：
10.1016/j.neulet.2004.02.070
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发表时间：
2004-05-27
影响因子：
2.5
通讯作者：
Fredrikson, M
中科院分区：
文献类型：
--
作者：
Furmark, T;Tillfors, M;Fredrikson, M
人类5-羟色胺转运体（5-HTT）基因启动子区的功能多态性与负面情绪和杏仁核活动有关。我们研究了杏仁核激活过程中的社交焦虑的情绪评级和5-HTT的遗传变异。[H-2 17例社交恐惧症患者在私下和公开演讲（基线和焦虑状态）时，应用正电子发射断层扫描仪（PET）评估杏仁核血流量。基因分型鉴定出5-HTT启动子区有长和短等位基因的患者。与长等位基因纯合子的受试者相比，具有一个或两个短等位基因拷贝的个体表现出显著增加的焦虑相关特征、状态焦虑和增强的右杏仁核对焦虑激发的反应水平。因此，5-HTT基因变异与社交恐惧症的症状严重程度和杏仁核兴奋性相关。(C)2004爱思唯尔爱尔兰有限公司保留所有权利。
A functional polymorphism in the promoter region of the human serotonin transporter (5-HTT) gene has been related to negative affect and amygdala activity. We studied amygdala activation during social anxiety provocation in relation to affective ratings and 5-HTT genetic variation.[H-2 O-15]positron emission tomography was used to estimate amygdala blood flow during private and public speaking (baseline and anxiety conditions) in 17 patients with social phobia. Genotyping identified patients with long and short alleles in the promoter region of the 5-HTT. Individuals with one or two copies of the short allele exhibited significantly increased levels of anxiety-related traits, state anxiety, and enhanced right amygdala responding to anxiety provocation, compared with subjects homozygous for the long allele. Thus, 5-HTT genetic variation was associated with symptom severity and amygdala excitability in social phobia. (C) 2004 Elsevier Ireland Ltd. All rights reserved.