In vivo amyloid imaging with PET in frontotemporal dementia
In vivo amyloid imaging with PET in frontotemporal dementia
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DOI：
10.1007/s00259-007-0523-1
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发表时间：
2008-01-01
影响因子：
9.1
通讯作者：
Kilander, Lena
中科院分区：
文献类型：
--
作者：
Engler, Henry;Santillo, Alexander Frizell;Kilander, Lena
背景N-甲基[11 C]2-（4 ′-甲氨基苯基）-6-羟基苯并噻唑（PIB）是一种具有淀粉样蛋白结合特性的正电子发射断层扫描（PET）示踪剂，其允许在体内测量阿尔茨海默病（AD）的脑淀粉样蛋白负荷。额颞叶痴呆（FTD）是一种综合征，可以在临床上很难区分AD，但在FTD淀粉样蛋白沉积是不是一个特征性的病理finding.Purpose-本研究的目的是探讨PIB保留在FTD.Methods 10例诊断FTD参与。诊断是基于临床和神经心理学检查，计算机断层扫描或磁共振成像扫描，PET与18氟-2-脱氧-d-葡萄糖（FDG）。将在感兴趣区域中测量的PIB保留归一化为参考区域（小脑）。将结果与先前从17名具有阳性PIB保留的AD患者和8名具有阴性PIB保留的健康对照（HC）获得的PIB保留数据进行比较。统计分析采用Students t检验，Bonferroni校正后显著性水平设为0.00625。（p < 0.0001）、顶叶（p < 0.0001）、颞叶（p=0.0001）和枕叶（p=0.0003）皮质以及壳核（p < 0.0001）。这些FTD患者的PIB摄取与任何地区的HC均无显著差异。然而，10例FTD患者中有2例表现出与AD患者相似的PIB潴留。因此，PIB可能有助于区分FTD和AD。
Background N-methyl[11C]2-(4'methylaminophenyl)-6-hydroxy-benzothiazole (PIB) is a positron emission tomography (PET) tracer with amyloid binding properties which allows in vivo measurement of cerebral amyloid load in Alzheimer's disease (AD). Frontotemporal dementia (FTD) is a syndrome that can be clinically difficult to distinguish from AD, but in FTD amyloid deposition is not a characteristic pathological finding.Purpose The aim of this study is to investigate PIB retention in FTD.Methods Ten patients with the diagnosis of FTD participated. The diagnosis was based on clinical and neuropsychological examination, computed tomography or magnetic resonance imaging scan, and PET with 18Fluoro-2-deoxy-d-glucose (FDG). The PIB retention, measured in regions of interest, was normalised to a reference region (cerebellum). The results were compared with PIB retention data previously obtained from 17 AD patients with positive PIB retention and eight healthy controls (HC) with negative PIB retention. Statistical analysis was performed with a students t-test with significance level set to 0.00625 after Bonferroni correction.Results Eight FTD patients showed significantly lower PIB retention compared to AD in frontal (p < 0.0001), parietal (p < 0.0001), temporal (p=0.0001), and occipital (p=0.0003) cortices as well as in putamina (p < 0.0001). The PIB uptake in these FTD patients did not differ significantly from the HC in any region. However, two of the 10 FTD patients showed PIB retention similar to AD patients.Conclusion The majority of FTD patients displayed no PIB retention. Thus, PIB could potentially aid in differentiating between FTD and AD.