A comparison of the hemodynamic effects of flow diverters on wide-necked and narrow-necked cerebral aneurysms
A comparison of the hemodynamic effects of flow diverters on wide-necked and narrow-necked cerebral aneurysms
复制标题
分流器对宽颈和窄颈脑动脉瘤血流动力学影响的比较
DOI：
10.1016/j.jocn.2011.10.015
复制
发表时间：
2012-11-01
影响因子：
2
通讯作者：
Liu, Jian-Min
中科院分区：
文献类型：
--
作者：
Wu, Yong-Fa;Yang, Peng-Fei;Liu, Jian-Min
血流导向器（FD）是新一代低孔隙率网状颅内支架，已被用作颅内动脉瘤的替代治疗方法。然而，它们的有效性在不同形态的动脉瘤之间存在差异。在本研究中，进行了计算流体动力学模拟，以检查FD对宽颈和窄颈脑动脉瘤血流动力学的影响。在理想窄颈和宽颈动脉瘤模型的瘤颈上展开了孔隙率为70%的FD补片。两种模型的动脉囊血流动力学均发生明显改变。在窄颈动脉瘤瘤颈的流入部分，峰值速度和壁面切应力分别降低了84%和91%。相比之下，在宽颈动脉瘤模型中，结果分别为47%和21%。这项研究表明，FD显着改变颅内动脉瘤内的血流动力学条件，这取决于动脉瘤形态。因此，对于不同形态的动脉瘤，应单独设计血流动力学修改。(C)2012爱思唯尔有限公司保留所有权利。
Flow diverters (FD), a new generation of intracranial stents with a low porosity mesh, have been applied as an alternative treatment for intracranial aneurysms. However, their efficacy varies among aneurysms of different morphology. In this study, computational fluid dynamic simulations were performed to examine the influence of an FD on the hemodynamics of wide-necked and narrow-necked cerebral aneurysms. An FD with 70% porosity mesh was deployed across the neck of an ideal narrow-necked and wide-neck aneurysm model. The hemodynamics at the aneurysmal sac were changed markedly in both models. At the inflow portion of the aneurysm neck of the narrow-necked aneurysm, the peak velocity and wall shear stress were reduced by 84% and 91%, respectively. By comparison, in the wide-necked aneurysm model, the results were 47% and 21%, respectively. This study demonstrates that the FD markedly altered the hemodynamic conditions inside intracranial aneurysms, depending on aneurysm morphology. Therefore, hemodynamic modifications should be individually designed for aneurysms with different morphology. (C) 2012 Elsevier Ltd. All rights reserved.