Heterogeneity of Particle Deposition by Pixel Analysis of 2D Gamma Scintigraphy Images
Heterogeneity of Particle Deposition by Pixel Analysis of 2D Gamma Scintigraphy Images
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DOI：
10.1089/jamp.2013.1095
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发表时间：
2015-06-01
影响因子：
3.4
通讯作者：
Donaldson, Scott
中科院分区：
文献类型：
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作者：
Bennett, William D.;Xie, Miao;Donaldson, Scott
背景：气道疾病中吸入颗粒沉积的异质性可能是肺生理变化的敏感指标。使用平面伽玛射线照相术，我们开发了新的方法来定位和量化肺中高（热）和低（冷）颗粒沉积的区域。在吸入放射性标记颗粒后，从健康成人受试者（n=31）和轻度囊性纤维化肺病（CF）患者（n=14）获得初始沉积和24小时保留图像（Tc 99 m-硫胶体，5.4 m MMAD）。右肺的初始沉积图像被标准化为（即，相同的中值像素值），然后除以相同个体中的透射（Tc 99 m）图像，以获得逐像素比率图像。热点被定义为沉积图像中的像素值大于透射率的2倍，冷点被定义为沉积图像小于透射率的0.5倍的像素。比较健康和CF受试者之间的热像素和冷像素与总肺像素的数量比（NR）以及热像素中的总计数与总肺计数的总和比（SR）。结果：轻度CF患者冷斑的NR值为0.22 +/- 0.047（CF），健康者为0.186 +/- 0.038（P
Background: Heterogeneity of inhaled particle deposition in airways disease may be a sensitive indicator of physiologic changes in the lungs. Using planar gamma scintigraphy, we developed new methods to locate and quantify regions of high (hot) and low (cold) particle deposition in the lungs.Methods: Initial deposition and 24 hour retention images were obtained from healthy (n=31) adult subjects and patients with mild cystic fibrosis lung disease (CF) (n=14) following inhalation of radiolabeled particles (Tc99m-sulfur colloid, 5.4m MMAD) under controlled breathing conditions. The initial deposition image of the right lung was normalized to (i.e., same median pixel value), and then divided by, a transmission (Tc99m) image in the same individual to obtain a pixel-by-pixel ratio image. Hot spots were defined where pixel values in the deposition image were greater than 2X those of the transmission, and cold spots as pixels where the deposition image was less than 0.5X of the transmission. The number ratio (NR) of the hot and cold pixels to total lung pixels, and the sum ratio (SR) of total counts in hot pixels to total lung counts were compared between healthy and CF subjects. Other traditional measures of regional particle deposition, nC/P and skew of the pixel count histogram distribution, were also compared.Results: The NR of cold spots was greater in mild CF, 0.22 +/- 0.047(CF) vs. 0.186 +/- 0.038 (healthy) (p