HYALURONATE RECEPTORS - KEY PLAYERS IN GROWTH, DIFFERENTIATION, MIGRATION AND TUMOR PROGRESSION
HYALURONATE RECEPTORS - KEY PLAYERS IN GROWTH, DIFFERENTIATION, MIGRATION AND TUMOR PROGRESSION
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DOI：
10.1016/0955-0674(94)90100-7
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发表时间：
1994-10-01
影响因子：
7.5
通讯作者：
PONTA, H
中科院分区：
文献类型：
--
作者：
SHERMAN, L;SLEEMAN, J;PONTA, H
透明质酸（HA）是细胞外基质的丰富组分，其被认为在许多细胞过程中至关重要，包括组织重塑、无细胞空间的产生、炎症和肿瘤发生。尽管细胞外基质中的几种充分表征的蛋白质与HA结合，但现在清楚的是，细胞也可以通过细胞表面HA结合蛋白直接结合HA并对其产生反应。已克隆并鉴定了编码这两个蛋白家族CD44和RHAMM的cDNA。这些蛋白质涉及许多生理过程，包括细胞迁移、淋巴细胞活化和肿瘤进展。虽然这些过程中的许多依赖于与HA的关联，但有些显然是HA独立的，这表明这些受体的其他配体可能参与其中。
Hyaluronate (HA) is an abundant component of extracellular matrix that is believed to be crucial in many cellular processes, including tissue remodeling, the creation of cell-free spaces, inflammation and tumorigenesis. Although several well characterized proteins within the extracellular matrix associate with HA, it is now clear that cells can also bind and respond to HA directly, via cell-surface HA-binding proteins. The cDNAs coding for two families of such proteins, CD44 and RHAMM, have been cloned and characterized. These proteins have been implicated in a number of physiological processes, including cell migration, lymphocyte activation and tumor progression. Although many of these processes depend on an association with HA, some are apparently HA-independent, suggesting that other ligands for these receptors may be involved.