The evolutionary arms race between transposable elements and piRNAs in Drosophila melanogaster
The evolutionary arms race between transposable elements and piRNAs in Drosophila melanogaster
复制标题
果蝇转座元件和 piRNA 之间的进化军备竞赛
DOI：
10.1186/s12862-020-1580-3
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发表时间：
2020-01-28
影响因子：
3.4
通讯作者：
Lu, Jian
中科院分区：
文献类型：
--
作者：
Luo, Shiqi;Zhang, Hong;Lu, Jian
piwi相互作用rna （piRNAs）是果蝇种系中特异性抑制转座因子（te）的小非编码rna。尽管我们对TE:piRNA相互作用的理解越来越深入，但TE和piRNA之间是否存在进化军备竞赛尚不清楚。结果我们研究了世界范围内d菌株的TEs和pirna的群体基因组学。腹。通过对代表性菌株子房TE含量与pirna丰度的相关性分析。研究人员发现，在6个TE家族中，TE与pirna呈正相关。我们的模拟进一步强调了TE活性和针对TE的净化选择强度是塑造TE与pirna之间相互作用的重要因素。我们的研究还表明，pirna的重新生成是抑制新入侵TEs的重要机制。结论在种群水平上，te的拷贝数与反义pirna的丰度之间存在一种进化军备竞赛。尽管TE和pirna之间的相互作用是复杂的，并且需要考虑许多因素来影响它们的相互作用动力学，但我们的研究结果表明，在研究果蝇TE插入的景观时，应该考虑pirna对TE的出现、抑制特异性和强度。这些结果加深了我们对pirna和te之间相互作用的理解，也为其他形式的基因组冲突的本质提供了新的见解。
BackgroundThepiwi-interacting RNAs (piRNAs) are small non-coding RNAs that specifically repress transposable elements (TEs) in the germline ofDrosophila. Despite our expanding understanding of TE:piRNA interaction, whether there is an evolutionary arms race between TEs and piRNAs was unclear.ResultsHere, we studied the population genomics of TEs and piRNAs in the worldwide strains ofD. melanogaster. By conducting a correlation analysis between TE contents and the abundance of piRNAs from ovaries of representative strains ofD. melanogaster, we find positive correlations between TEs and piRNAs in six TE families. Our simulations further highlight that TE activities and the strength of purifying selection against TEs are important factors shaping the interactions between TEs and piRNAs. Our studies also suggest that the de novo generation of piRNAs is an important mechanism to repress the newly invaded TEs.ConclusionsOur results revealed the existence of an evolutionary arms race between the copy numbers of TEs and the abundance of antisense piRNAs at the population level. Although the interactions between TEs and piRNAs are complex and many factors should be considered to impact their interaction dynamics, our results suggest the emergence, repression specificity and strength of piRNAs on TEs should be considered in studying the landscapes of TE insertions inDrosophila. These results deepen our understanding of the interactions between piRNAs and TEs, and also provide novel insights into the nature of genomic conflicts of other forms.