Differences in the humoral autoreactivity to zinc transporter 8 between childhood- and adult-onset type 1 diabetes in Japanese patients
Differences in the humoral autoreactivity to zinc transporter 8 between childhood- and adult-onset type 1 diabetes in Japanese patients
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DOI：
10.1016/j.clim.2010.10.007
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发表时间：
2011-02-01
影响因子：
8.6
通讯作者：
Eguchi, Katsumi
中科院分区：
文献类型：
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作者：
Kawasaki, Eiji;Nakamura, Kan;Eguchi, Katsumi
本研究的目的是评估锌转运蛋白8 （ZnT8）的体液自身反应性，这取决于1型糖尿病（T1D）的临床表型。57例儿童发病、97例成人发病和85例暴发性T1D患者采用羧端ZnT8构建体放射免疫测定ZnT8自身抗体（ZnT8A）。ZnT8A频率在儿童期发病的患者中较高，随着发病年龄的增加而降低，从70% ~ 24% （p趋势）
The aim of this study was to evaluate the humoral autoreactivity to zinc transporter 8 (ZnT8) depending on the clinical phenotype of type 1 diabetes (T1D). ZnT8 autoantibodies (ZnT8A) were determined by radioimmunoassay using carboxy-terminal ZnT8 constructs in 57 childhood-onset, 97 adult-onset, and 85 fulminant T1D. The ZnT8A frequency was higher in childhood-onset patients and decreased with increasing age of onset from 70% to 24% (P-trend