Genetic linkage is excluded for the D2-dopamine receptor lambda HD2G1 and flanking loci on chromosome 11q22-q23 in Tourette syndrome.
Genetic linkage is excluded for the D2-dopamine receptor lambda HD2G1 and flanking loci on chromosome 11q22-q23 in Tourette syndrome.
复制标题
排除抽动秽语综合征中 D2-多巴胺受体 lambda HD2G1 和染色体 11q22-q23 侧翼位点的遗传连锁。
DOI：
10.1159/000153914
复制
发表时间：
1990
期刊：
影响因子：
1.8
通讯作者：
Oostra,B
中科院分区：
文献类型：
--
作者：
Devor,EJ;Grandy,DK;Civelli,O;Litt,M;Burgess,AK;Isenberg,KE;vandeWetering,BJ;Oostra,B
通过诊断为抽动秽语综合征的先证者确定的15个家庭（n = 166）的遗传连锁研究进行了染色体11 q22-q23上的D2-多巴胺受体和侧翼位点。所有探针均排除紧密连锁，并获得高达± 20%重组的排除区域。基于原始图谱数据的重叠排除区域允许排除Tourette综合征中DRD 2基因座的整个区域。
A genetic linkage study of fifteen families (n = 166) ascertained through probands diagnosed for Tourette syndrome was carried out for the D2-dopamine receptor and flanking loci on chromosome 11q22-q23. Tight linkage was excluded for all probes and regions of exclusion up to ± 20% recombination were obtained. Overlapping regions of exclusion based upon primary map data permit exclusion of the entire region of the DRD2 locus in Tourette syndrome.