Distribution of coronary artery calcium by race, gender, and age - Results from the Multi-Ethnic Study of Atherosclerosis (MESA)
Distribution of coronary artery calcium by race, gender, and age - Results from the Multi-Ethnic Study of Atherosclerosis (MESA)
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DOI：
10.1161/circulationaha.105.580696
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发表时间：
2006-01-03
期刊：
影响因子：
37.8
通讯作者：
Kronmal, RA
中科院分区：
文献类型：
--
作者：
McClelland, RL;Chung, HJ;Kronmal, RA
冠状动脉钙化（CAC）已被证明与冠心病的风险有关。多种族研究的动脉粥样硬化（梅萨）提供了一个独特的机会，检查CAC的分布的基础上，年龄，性别，种族/民族在一个队列的临床心血管疾病和治疗diabetes.Methods和Results-MESA是一个前瞻性队列研究，旨在探讨亚临床心血管疾病的多种族队列的临床心血管疾病。用非参数技术估计CAC分布的最大值。治疗的糖尿病患者从分析中排除。共有6110人纳入分析，其中53%为女性，平均年龄为62岁。男性的钙水平高于女性，随着年龄的增长，钙的含量和患病率稳步上升。不同种族之间的钙含量存在显著差异，这些相关性在年龄和性别之间存在差异。就女性而言，白人的平均寿命最高，西班牙裔的平均寿命最低;然而，在最年长的年龄组中，华裔女性的平均寿命最低。总的来说，中国和黑人妇女处于中间地位，其顺序取决于年龄。对于男性来说，白人的收入一直是最高的，西班牙裔的收入是第二高的。黑人在年轻时最低，中国人在老年时最低。在梅萨的公共网站（http：www.mesa-nhlbi.org），一个交互式的形式，允许一个人输入年龄，性别，种族/民族，和CAC分数，以获得相应的估计percention.Conclusions-The信息提供这里可以用来检查是否有一个病人有一个高CAC分数相对于其他人具有相同的年龄，性别，和种族/民族谁没有临床心血管疾病或治疗糖尿病。
Background-Coronary artery calcium (CAC) has been demonstrated to be associated with the risk of coronary heart disease. The Multi-Ethnic Study of Atherosclerosis ( MESA) provides a unique opportunity to examine the distribution of CAC on the basis of age, gender, and race/ethnicity in a cohort free of clinical cardiovascular disease and treated diabetes.Methods and Results-MESA is a prospective cohort study designed to investigate subclinical cardiovascular disease in a multiethnic cohort free of clinical cardiovascular disease. The percentiles of the CAC distribution were estimated with nonparametric techniques. Treated diabetics were excluded from analysis. There were 6110 included in the analysis, with 53% female and an average age of 62 years. Men had greater calcium levels than women, and calcium amount and prevalence were steadily higher with increasing age. There were significant differences in calcium by race, and these associations differed across age and gender. For women, whites had the highest percentiles and Hispanics generally had the lowest; in the oldest age group, however, Chinese women had the lowest values. Overall, Chinese and black women were intermediate, with their order dependent on age. For men, whites consistently had the highest percentiles, and Hispanics had the second highest. Blacks were lowest at the younger ages, and Chinese were lowest at the older ages. At the MESA public website (http://www.mesa-nhlbi.org), an interactive form allows one to enter an age, gender, race/ethnicity, and CAC score to obtain a corresponding estimated percentile.Conclusions-The information provided here can be used to examine whether a patient has a high CAC score relative to others with the same age, gender, and race/ethnicity who do not have clinical cardiovascular disease or treated diabetes.