Origin and dynamics of extraclassical suppression in the lateral geniculate nucleus of the macaque monkey
Origin and dynamics of extraclassical suppression in the lateral geniculate nucleus of the macaque monkey
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DOI：
10.1016/j.neuron.2007.11.019
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发表时间：
2008-01-10
期刊：
影响因子：
16.2
通讯作者：
Usrey, W. Martin
中科院分区：
文献类型：
--
作者：
Alitto, Henry J.;Usrey, W. Martin
在外侧膝状体（LGN）中，除了经典的中央/环绕感受野神经元外，还有一个非经典的非线性环绕，可以强烈抑制LGN反应。这种形式的抑制可能在调节LGN对视觉刺激的反应增益中起重要作用。我们在警觉和麻醉的猕猴中进行了实验，以量化LGN中的经典外抑制，并确定前馈和反馈通路在LGN抑制产生中的作用。结果表明，大细胞神经元的抑制比小细胞神经元显着更强，抑制出现太快，参与皮层反馈。此外，视网膜提供的抑制量与LGN中的抑制量没有显著差异。这些结果表明，在猕猴LGN的经典外抑制依赖于前馈机制，并建议在皮层的抑制可能包括在视网膜中建立的组件。
In addition to the classical, center/surround receptive field of neurons in the lateral geniculate nucleus (LGN), there is an extraclassical, nonlinear surround that can strongly suppress LGN responses. This form of suppression likely plays an important role in adjusting the gain of LGN responses to visual stimuli. We performed experiments in alert and anesthetized macaque monkies to quantify extraclassical suppression in the LGN and determine the roles of feedforward and feedback pathways in the generation of LGN suppression. Results show that suppression is significantly stronger among magnocellular neurons than parvocellular neurons and that suppression arises too quickly for involvement from cortical feedback. Furthermore, the amount of suppression supplied by the retina is not significantly different from that in the LGN. These results indicate that extraclassical suppression in the macaque LGN relies on feedforward mechanisms and suggest that suppression in the cortex likely includes a component established in the retina.