Downregulation of the Wnt inhibitor CXXC5 predicts a better prognosis in acute myeloid leukemia
Downregulation of the Wnt inhibitor CXXC5 predicts a better prognosis in acute myeloid leukemia
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DOI：
10.1182/blood-2014-12-613703
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发表时间：
2015-05-07
期刊：
影响因子：
20.3
通讯作者：
Grimwade, David
中科院分区：
文献类型：
--
作者：
Kuehnl, Andrea;Valk, Peter J. M.;Grimwade, David
5 q31上的CXXC 5基因在伴有del（5 q）的急性髓系白血病（AML）中经常缺失，这表明CXXC 5的失活可能在白血病发生中起作用。在这里，我们研究了AML中CXXC 5表达的功能和预后意义。CXXC 5 mRNA在伴有MLL重排、t（8; 21）和GATA 2突变的AML中下调。作为CXXC 5失活的机制，我们发现了通过启动子甲基化进行表观遗传沉默的证据。CXXC 5表达低于中位水平的患者复发率较低（45% vs59%; P = 0.007），总生存率较好（OS，46% vs28%; P
The gene CXXC5 on 5q31 is frequently deleted in acute myeloid leukemia (AML) with del(5q), suggesting that inactivation of CXXC5 might play a role in leukemogenesis. Here, we investigated the functional and prognostic implications of CXXC5 expression in AML. CXXC5 mRNA was downregulated in AML with MLL rearrangements, t(8; 21) and GATA2 mutations. As a mechanism of CXXC5 inactivation, we found evidence for epigenetic silencing by promoter methylation. Patients with CXXC5 expression below the median level had a lower relapserate (45% vs59%; P = .007) and a better over all survival (OS, 46% vs28%; P