Pathophysiology of Migraine Disorder
Pathophysiology of Migraine Disorder
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DOI：
10.1007/978-3-030-75239-2_2
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发表时间：
2021
期刊：
影响因子：
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通讯作者：
B. Mueller;N. Diaz;Jihan Grant
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文献类型：
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作者：
B. Mueller;N. Diaz;Jihan Grant
尽管偏头痛被描述了几千年，这种疾病的病理生理学仍然没有完全理解。偏头痛是感觉功能障碍的一种形式，具有许多表现（偏头痛的病理生理学和遗传学。头痛.第88-99页; Goadsby等人，Physiol Rev 97（2）：553-622，2017）。偏头痛患者表现出光异常性疼痛和功能障碍的基线中枢感觉处理，表明偏头痛患者的大脑即使在基线时也不同于非偏头痛患者（Kim等人，Cephalalgia 30（1）：53-61，2010; Vanagaite等人，Cephalalalgia 17（7）：733-741，1997）。已知遗传学在偏头痛中起作用，因为在一级亲属和患有偏头痛的同卵双胞胎中，偏头痛的发病率在统计学上更高（Goadsby和Holland，Neurol Clin 37（4）：651-671，2019）。检查潜在遗传模式的研究一直相互矛盾，表明偏头痛的病因可能源于基因和环境之间的复杂相互作用（偏头痛的病理生理学和遗传学。头痛.第88-99页）。有先兆的偏头痛与家族性偏瘫性偏头痛等疾病存在一致的相关性，这说明了遗传学的重要性（偏头痛的病理生理学和遗传学。头痛.第88-99页）。此外，环境因素如天气变化和不同的食物已知在偏头痛的产生中起着重要作用。本章将通过对偏头痛的四个主要阶段：先兆、先兆、头痛和后症状的检查，回顾偏头痛病理生理学的现有知识。
Despite migraine being described for thousands of years, the pathophysiology of this disorder is still not completely understood. Migraine is a form of sensory dysfunction, with many manifestations (Pathophysiology and Genetics of Migraine. Headache. p. 88–99; Goadsby et al., Physiol Rev 97(2):553–622, 2017). Migraineurs exhibit photic allodynia and dysfunctional baseline central sensory processing indicating the brain of a migraineur differs from a nonmigraineur even at baseline (Kim et al., Cephalalgia 30(1):53–61, 2010; Vanagaite et al., Cephalalgia 17(7):733–741, 1997). Genetics are known to play a part in migraine as there is a statistically higher incidence of migraine amongst first degree relatives and in identical twins with migraine (Goadsby and Holland, Neurol Clin 37(4):651–671, 2019). Studies examining the potential mode of inheritance have been conflicting, indicating the etiology of migraine likely stems from a complex interaction between genes and the environment (Pathophysiology and Genetics of Migraine. Headache. p. 88–99). There is a consistent correlation of migraine with aura with disorders such as familial hemiplegic migraine illustrating the importance of genetics (Pathophysiology and Genetics of Migraine. Headache. p. 88–99). In addition, environmental triggers such as changes in weather and different food are known to play a significant role in migraine generation. This chapter will review the current knowledge of the pathophysiology of migraine through an examination of the four major phases of a migraine: premonitory, aura, headache, and postdrome.