Identification of differentially expressed genes in cervical cancer by bioinformatics analysis
Identification of differentially expressed genes in cervical cancer by bioinformatics analysis
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生物信息学分析鉴定宫颈癌差异表达基因
DOI：
10.3892/ol.2018.8953
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发表时间：
2018-08-01
期刊：
影响因子：
2.9
通讯作者：
Zhou, Yanhong
中科院分区：
文献类型：
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作者：
Ge, Yanshan;Zhang, Chaoyang;Zhou, Yanhong
宫颈癌是最常见的妇科恶性肿瘤。近年来，宫颈癌的发病率有年轻化的趋势。由于近几十年来宫颈细胞学筛查导致宫颈癌和癌前病变的早期发现和治疗，宫颈癌发病率和死亡率已大大降低。宫颈癌的早期症状有哪些？宫颈癌的早期症状有哪些然而，宫颈癌的患病率和复发率每年都在增加。目前迫切需要更好地了解宫颈癌发展的分子机制。本研究使用基因表达综合数据库中的科学信息检索下载GSE 26511数据集，该数据集包含39个样本，包括19个宫颈癌淋巴结阳性样本和20个宫颈癌淋巴结阴性样本。通过基因本体论分析、京都基因百科全书和基因组分析以及加权基因共表达网络分析，发现了1,263个影响生物学过程的差异表达基因，包括“细胞周期过程”、“信号通路”、“免疫反应”、“细胞活化”、“免疫系统过程的调节”和“炎症反应”。这些方面应成为今后宫颈癌研究的重点。
Cervical cancer is the most common gynecological malignancy. In recent years, the incidence of cervical cancer has had a younger trend. Cervical cancer morbidity and mortality rates have been significantly reduced due to recent decades of cervical cytology screening leading to the early detection and treatment of cervical cancer and precancerous lesions. There are a number of methods used to treat cervical cancer and improve the survival rate. However, the prevalence and recurrence rates of cervical cancer are increasing every year. There is an urgent requirement for a better understanding of the molecular mechanism cervical cancer development. The present study used scientific information retrieval from the Gene Expression Omnibus database to download the GSE26511 dataset, which contained 39 samples, including 19 cervical cancer lymph node-positive samples and 20 cervical cancer lymph node-negative samples. Using Gene Ontology analysis, Kyoto Encyclopedia of Genes and Genomes analysis, and weighted gene co-expression network analysis, 1,263 differentially expressed genes were found that affected the biological processes, including 'cell cycle process', 'signaling pathways', 'immune response', 'cell activation', 'regulation of immune system process' and 'inflammatory response'. These areas should be the focus of study for cervical cancer in the future.