Positioning sensory terminals in the olfactory lobe of Drosophila by Robo signaling
Positioning sensory terminals in the olfactory lobe of Drosophila by Robo signaling
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DOI：
10.1242/dev.01083
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发表时间：
2004-05-01
期刊：
影响因子：
4.6
通讯作者：
Rodrigues, V
中科院分区：
文献类型：
--
作者：
Jhaveri, D;Saharan, S;Rodrigues, V
嗅觉受体神经元和嗅叶的中间神经元被组织在称为肾小球的不同单位中。我们已经使用的表达模式和遗传分析，以证明一个组合的代码的回旋（机器人）受体的行为定位感觉终端内的嗅叶。感觉神经元组具有Robo和Robo3的不同混合物，并且通过功能丧失或异位表达导致水平的破坏导致异常靶向。在野生型中，大多数神经元向对侧叶发出侧支。我们的数据表明，大脑半球轴突的指导是由Slit依赖的Robo2信号介导的。在叶内的不同位置的感觉乔木的位置允许与投射神经元的短程相互作用，导致肾小球的形成。
Olfactory receptor neurons and the interneurons of the olfactory lobe are organized in distinct units called glomeruli. We have used expression patterns and genetic analysis to demonstrate that a combinatorial code of Roundabout (Robo) receptors act to position sensory terminals within the olfactory lobe. Groups of sensory neurons possess distinct blends of Robo and Robo3 and disruption of levels by loss-of-function or ectopic expression results in aberrant targeting. In the wild type, most of the neurons send collateral branches to the contralateral lobe. Our data suggests that guidance of axons across brain hemispheres is mediated by Slit-dependent Robo2 signaling. The location of sensory arbors at distinct positions within the lobe allows short-range interactions with projection neurons leading to formation of the glomeruli.