Reelin functions beyond neuronal migration: from synaptogenesis to network activity modulation
Reelin functions beyond neuronal migration: from synaptogenesis to network activity modulation
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DOI：
10.1016/j.conb.2020.10.009
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发表时间：
2021-02-01
影响因子：
5.7
通讯作者：
Albadri, Shahad
中科院分区：
文献类型：
--
作者：
Faini, Giulia;Del Bene, Filippo;Albadri, Shahad
Reelin是一种细胞外基质的糖蛋白，多年来一直是研究的焦点，主要是由于它在细胞迁移中的作用。在这里，我们报告了该分子及其下游途径在有丝分裂后神经元中的作用，以及它们如何促进神经回路的组装、完善和功能。越来越多的证据表明Reelin在轴突引导、突触发生和树突棘形成中起着重要作用。特别是，新的证据指出在轴突靶向和细化靶点的直接作用。此外，最近的研究进展强调了Reelin在调节突触活性、可塑性和行为以及直接调节GABA受体表达和稳定性方面的新功能。我们在神经发育障碍的背景下讨论这些发现。
Reelin, a glycoprotein of the extracellular matrix, has been the focus of several studies over the years, mostly for its role in cell migration. Here we report the role of this molecule and of its downstream pathways in post-mitotic neurons and how they contribute to neural circuit assembly, refinement and function. Accumulating evidence has pointed at a major role for Reelin in axonal guidance, synaptogenesis and dendritic spine formation. In particular, new evidence points at a direct role in axonal targeting and refinement at the target site. In addition, recent advances highlight new functions of Reelin in the modulation of synaptic activity, plasticity and behavior and in the direct regulation of GABA receptors expression and stability. We discuss these findings in the context of neurodevelopmental disorders.