Prognostic significance of PIK3CA and SOX2 in Asian patients with lung squamous cell carcinoma.
Prognostic significance of PIK3CA and SOX2 in Asian patients with lung squamous cell carcinoma.
复制标题
DOI：
10.3892/ijo.2014.2742
复制
发表时间：
2015-02
影响因子：
5.2
通讯作者：
Gemma A
中科院分区：
文献类型：
--
作者：
Iijima Y;Seike M;Noro R;Ibi T;Takeuchi S;Mikami I;Koizumi K;Usuda J;Gemma A
人类基因组研究的最新进展表明，肺鳞状细胞癌（SQCC）的致癌驱动突变可能与多个基因的改变有关。FGFR 1、PIK 3CA和SOX 2基因被认为是SQCC的候选驱动基因。本研究的目的是评估SQCC中FGFR 1、PIK 3CA和SOX 2蛋白的表达，并确定这些蛋白的表达是否可用作预后生物标志物。我们通过免疫组化分析评估了FGFR 1、PIK 3CA和SOX 2表达与来自中国、美国和日本的I-III期肺SQCC患者总生存期的关系。FGFR 1阳性、PIK 3CA阴性和SOX 2阳性染色均显示出更好的生存趋势，尽管在57例中国患者队列中差异无统计学意义。在中国队列中，与PIK 3CA阳性或SOX 2阴性染色的患者相比，PIK 3CA阴性和SOX 2阳性染色的患者（PIK 3CA −/SOX 2+）显示出更好的预后（P=0.04）。PIK 3CA −/SOX 2+分类具有预后意义的稳健性在一组独立的66例日本队列患者中得到验证（P=0.007）。对I期日本SQCC患者进行了单独评估，PIK 3CA −/SOX 2+患者的生存率显著高于PIK 3CA阳性或SOX 2阴性患者（P=0.03）。在亚洲I期患者的单变量和多变量考克斯比例风险模型中，PIK 3CA −/SOX 2+分类与生存率统计学显著相关，是一个独立的预后因素。PIK 3CA和SOX 2蛋白表达的分类有助于预测亚洲I期肺SQCC患者的预后。
The recent development of human genome studies has demonstrated the possibility of alteration of several genes as oncogenic driver mutations of lung squamous cell carcinoma (SQCC). FGFR1, PIK3CA and SOX2 genes have been recognized as candidate driver genes of SQCC. The aim of the present study was to evaluate FGFR1, PIK3CA and SOX2 protein expression in SQCC and determine whether the expression of these can be used as prognostic biomarkers. We evaluated the relationships between FGFR1, PIK3CA and SOX2 expression by immunohistochemical analysis and overall survival in lung SQCC patients with stage I–III that originated from China, United States and Japan. FGFR1-positive, PIK3CA-negative and SOX2-positive staining each showed trends toward better survival, although the differences were not statistically significant in a Chinese cohort of 57 patients. Patients with PIK3CA-negative and SOX2-positive staining (PIK3CA−/SOX2+) showed better prognosis compared with those with PIK3CA-positive or SOX2-negative staining in the Chinese cohort (P=0.04). The robustness of PIK3CA−/SOX2+ classification as having prognostic significance was validated in an independent set of 66 Japanese cohort patients (P=0.007). Japanese SQCC patients with stage I were evaluated separately and PIK3CA−/SOX2+ cases had significantly better survival than the group with PIK3CA-positive or SOX2-negative status (P=0.03). In univariate and multivariable Cox proportional hazards models of Asian stage I patients, the PIK3CA−/SOX2+ classification was statistically significantly associated with survival and was an independent prognostic factor. Classification by PIK3CA and SOX2 protein expression is useful for predicting the prognosis of Asian patients with lung SQCC with stage I.
登录
查看更多内容
影响因子：
158.5
作者：
Lynch, TJ;Bell, DW;Haber, DA
通讯作者：
Haber, DA
DOI：
10.1056/nejmoa1214271
发表时间：
2013-03-21
期刊：
The New England journal of medicine
影响因子：
--
作者：
Friboulet L;Olaussen KA;Pignon JP;Shepherd FA;Tsao MS;Graziano S;Kratzke R;Douillard JY;Seymour L;Pirker R;Filipits M;André F;Solary E;Ponsonnailles F;Robin A;Stoclin A;Dorvault N;Commo F;Adam J;Vanhecke E;Saulnier P;Thomale J;Le Chevalier T;Dunant A;Rousseau V;Le Teuff G;Brambilla E;Soria JC
通讯作者：
Soria JC
影响因子：
5.3
作者：
Kawano, Osamu;Sasaki, Hidefumi;Fujii, Yoshitaka
通讯作者：
Fujii, Yoshitaka
影响因子：
51.1
作者：
Mitsudomi, Tetsuya;Morita, Satoshi;Fukuoka, Masahiro
通讯作者：
Fukuoka, Masahiro
影响因子：
45.3
作者：
Scagliotti, Giorgio Vittorio;Parikh, Purvish;Gandara, David
通讯作者：
Gandara, David