Exploring anxiety symptoms in a large-scale twin study of children with autism spectrum disorders, their co-twins and controls
Exploring anxiety symptoms in a large-scale twin study of children with autism spectrum disorders, their co-twins and controls
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DOI：
10.1111/jcpp.12068
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发表时间：
2013-11-01
影响因子：
7.6
通讯作者：
Happe, Francesca
中科院分区：
文献类型：
--
作者：
Hallett, Victoria;Ronald, Angelica;Happe, Francesca
背景虽然许多患有自闭症谱系障碍(ASDS)的儿童经历了焦虑的困难，但这些困难的表现仍然没有得到解决。目前的研究评估了一大批基于人群的双胞胎样本，年龄在10-15岁之间。研究采用表型分析的方法，对患有自闭症的儿童、其未受影响的同卵双胞胎和对照样本中的焦虑症状进行研究。80个对照家庭也包括在内。修订的儿童焦虑和抑郁量表(Chorpia，Yim，Moffitt，Uemoto&Francis，2000)已经完成(自我报告和父母报告)，以及诊断和认知测试。儿童被分为4组(A)ASD(B)更广泛的自闭症表型(BAP：主要是患有ASD的儿童的同卵双胞胎，具有较高的亚临床自闭症特征)(C)未受影响的同卵双胞胎(既没有ASD也没有BAP)(D)对照组。结果ASD和BAP组的儿童在所有父母评定(尽管不是儿童评定)的焦虑量表上的得分显著高于对照组。在ASD组和BAP组之间，父母评定的焦虑子量表中的任何一个都没有显著差异。与对照组相比，未受影响的同卵双胞胎表现出显著的社交焦虑、一般性焦虑和恐慌症状。观察到某些焦虑分量表与智商和自闭症症状之间存在显著的相关性。例如，父母评定的社交焦虑越大，智商越高，社交和沟通障碍也越多。在患有自闭症儿童的焦虑报告中观察到显著的评价者间相关性(r=0.27-0.54；p
BackgroundAlthough many children with autism spectrum disorders (ASDs) experience difficulties with anxiety, the manifestation of these difficulties remains unresolved. The current study assessed anxiety in a large population-based twin sample, aged 10-15years. Phenotypic analyses were used to explore anxiety symptoms in children with ASDs, their unaffected co-twins and a control sample.MethodsParticipants included 146 families from the Twins Early Development Study (TEDS) where one or both children had a suspected ASD. Eighty control families were also included. The Revised Child Anxiety and Depression scale (Chorpita, Yim, Moffitt, Umemoto & Francis, 2000) was completed (self- and parent-report), along with diagnostic and cognitive tests. Children were categorized into four groups (a) ASD (b) Broader Autism Phenotype (BAP: mainly co-twins of children with ASDs, with high subclinical autistic traits) (c) unaffected co-twins (with neither ASDs nor BAP) (d) controls.ResultsChildren in the ASD and BAP groups scored significantly higher than controls for all parent-rated (although not child-rated) anxiety subscales. There were no significant differences between the ASD and BAP groups for any of the parent-rated anxiety subscales. Compared with controls, unaffected co-twins showed significantly heightened Social Anxiety, Generalized Anxiety, and Panic symptoms. Significant associations were observed between certain anxiety subscales and both IQ and ASD symptoms. For example, greater parent-rated Social Anxiety was associated with higher IQ and increased social and communicative impairments. Significant interrater correlations were observed for anxiety reports in children with ASDs (r=.27-.54; p