Familial occurrence of papillary thyroid carcinoma

Familial occurrence of papillary thyroid carcinoma
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甲状腺乳头状癌有家族性发生

DOI：
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发表时间：
1980
期刊：
Cancer
影响因子：
6.2
通讯作者：
Mds I. 0. BRENNHOVD
Mds I. 0. BRENNHOVD
中科院分区：
医学1区
文献类型：
--
作者：
MD KNUT LOTE;MD KAI ANDERSEN;MD ELI NORDAL;Mds I. 0. BRENNHOVD

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我们报告了两例来自挪威北方的患者，分别有7例和4例甲状腺乳头状癌，这些患者在其他方面都很健康，没有接受过放射治疗。虽然组织学特征是可比的，患者的年龄在诊断时是较低的，淋巴结转移是更常见的家族性甲状腺乳头状癌比非家族性的情况下，从同一地区。我们的结论是，遗传因素可以使患者的甲状腺乳头状癌的发展。本地发病率高可能是由于易感基因和环境因素之间的相互作用。
We report two kindreds from northern Norway with 7 and 4 cases of papillary thyroid carcinoma in otherwise healthy, nonirradiated subjects. While histologic features were comparable the patient's age at the time of diagnosis was lower and lymph node metastases were more frequent in familial than in nonfamilial cases of papillary thyroid carcinoma from the same region. We conclude that genetic factors can predispose the patient for development of papillary thyroid carcinoma. The high local incidence may be due to interaction between susceptibility gene(s) and environmental factors.