Individual differences in trait anhedonia: a structural and functional magnetic resonance imaging study in non-clinical subjects
Individual differences in trait anhedonia: a structural and functional magnetic resonance imaging study in non-clinical subjects
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DOI：
10.1038/sj.mp.4002021
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发表时间：
2007-08-01
影响因子：
11
通讯作者：
Lepage, M.
中科院分区：
文献类型：
--
作者：
Harvey, P-O;Pruessner, J.;Lepage, M.
快感缺乏，即从愉快的经历中获得快乐的能力降低，是重度抑郁症和精神分裂症的一个关键症状。降低的享乐能力也可以作为非临床受试者的持久特征来测量。这种改变的享乐能力可能是一个基本的神经心理生理功能障碍和脆弱性标志，可能先于和有助于发展精神疾病的责任的结果。在非临床个体的特质性快感缺失的结构和功能的神经相关的表征可能提供新的见解，为早期发现这种精神疾病。29名非临床受试者在蒙特利尔神经学研究所接受扫描。特质性快感缺乏使用查普曼修订的身体快感缺乏量表测量。半自动化和自动化结构MRI分割技术被用来探索结构相关的特质快感缺失。29名受试者中有17名还接受了功能成像任务，检查了对情感刺激的反应，以确定特质快感缺失的功能相关性。特质性快感缺乏与前尾状核体积呈负相关，与前额叶腹内侧皮层在处理正面信息时的活动呈正相关。这些研究结果可能反映了一种特定的脆弱性的精神情感障碍的发展，并建议特质快感缺失可能与基底神经节的体积减少和前额叶功能异常享乐过程中。
Anhedonia, the reduced capacity to gain pleasure from pleasurable experiences, is a key symptom of major depression and schizophrenia. Reduced hedonic capacity can also be measured as an enduring trait in non-clinical subjects. Such altered hedonic capacity is likely the result of a basic neuropsychophysiological dysfunction and a vulnerability marker that potentially precedes and contributes to the liability of developing psychiatric disorders. The characterization of the structural and functional neural correlates of trait anhedonia in nonclinical individuals may provide new insights for the early detection of such psychiatric diseases. Twenty-nine non-clinical subjects were scanned at the Montreal Neurological Institute. Trait anhedonia was measured using the Chapman Revised Physical Anhedonia Scale. Semi-automated and automated structural MRI segmentation techniques were used to explore structural correlates of trait anhedonia. Seventeen of the 29 subjects also underwent a functional imaging task where responses to the viewing of affective stimuli were examined to identify the functional correlates of trait anhedonia. Trait anhedonia was inversely related to anterior caudate volume, but positively related to ventromedial prefrontal cortex activity during the processing of positive information. These findings may reflect a specific kind of vulnerability for the development of psychiatric affective disorders and suggest that trait anhedonia may be linked to a volumetric reduction in the basal ganglia and to a prefrontal functional abnormality during hedonic processing.