Uncoupling Therapeutic Efficacy from Immune-Related Adverse Events in Immune Checkpoint Blockade.
Uncoupling Therapeutic Efficacy from Immune-Related Adverse Events in Immune Checkpoint Blockade.
复制标题
免疫检查点阻断中免疫相关不良事件的解偶联治疗有效性。
DOI：
10.1016/j.isci.2020.101580
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发表时间：
2020-10-23
期刊：
影响因子：
5.8
通讯作者：
You M
中科院分区：
文献类型：
--
作者：
Hu W;Wang G;Wang Y;Riese MJ;You M
使用靶向免疫检查点分子（包括程序性死亡-1（PD-1）、PD配体-1（PD-L1）和细胞毒性T淋巴细胞相关抗原（CTLA）-4）的单克隆抗体的免疫疗法在许多类型的癌症的治疗中已经变得突出。然而，大量接受免疫检查点抑制剂（ICI）治疗的患者发生免疫相关不良事件（irAE）。irAE可影响任何器官系统，尽管大多数在临床上可管理，但irAE可导致死亡或长期发病。可以预测irAE的因素仍然难以捉摸。需要了解ICI诱导的irAE的病因以及限制这些不良事件的方法。在这篇综述中，我们提供了有关ICI疗效和ICI诱导的irAE机制的基础科学和临床见解。我们进一步提供了对可能将irAE与ICI杀死肿瘤细胞的能力解偶联的方法的见解。临床医学;免疫学;癌症
Immunotherapy with monoclonal antibodies targeting immune checkpoint molecules, including programmed death-1 (PD-1), PD ligand-1 (PD-L1), and cytotoxic T-lymphocyte-associated antigen (CTLA)-4, has become prominent in the treatment of many types of cancer. However, a significant number of patients treated with immune checkpoint inhibitors (ICIs) develop immune-related adverse events (irAEs). irAEs can affect any organ system, and although most are clinically manageable, irAEs can result in mortality or long-term morbidity. Factors that can predict irAEs remain elusive. Understanding the etiology of ICI-induced irAEs and ways to limit these adverse events are needed. In this review, we provide basic science and clinical insights on the mechanisms responsible for ICI efficacy and ICI-induced irAEs. We further provide insights into approaches that may uncouple irAEs from the ability of ICIs to kill tumor cells. Clinical Medicine; Immunology; Cancer
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