TROPICAL CANINE PANCYTOPENIA - CLINICAL, HEMATOLOGIC, AND SEROLOGIC RESPONSE OF DOGS TO EHRLICHIA-CANIS INFECTION, TETRACYCLINE THERAPY, AND CHALLENGE INOCULATION
TROPICAL CANINE PANCYTOPENIA - CLINICAL, HEMATOLOGIC, AND SEROLOGIC RESPONSE OF DOGS TO EHRLICHIA-CANIS INFECTION, TETRACYCLINE THERAPY, AND CHALLENGE INOCULATION
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DOI：
10.1093/infdis/130.4.357
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发表时间：
1974-01-01
影响因子：
6.4
通讯作者：
RISTIC, M
中科院分区：
文献类型：
--
作者：
BUHLES, WC;HUXSOLL, DL;RISTIC, M
为进一步阐明热带犬全血细胞减少症（TCP）的发病机制，对14只德国牧羊犬进行了犬埃立克体感染、四环素治疗和攻毒接种后的评价。9只犬发生了严重的慢性TCP，其特征为严重的全血细胞减少、出血和继发性细菌感染。在所有犬中，感染后抗体滴度增加超过80天，所有犬均发生高丙种球蛋白血症。严重慢性病犬接受四环素治疗终止感染后血液学恢复时间延长且不完全。治疗后血清γ-球蛋白水平恢复正常。第二次接种E.犬的再感染和高丙种球蛋白血症，但不同程度的血清抗体增加。结果提示再生障碍性贫血可能是严重慢性TCP的重要发病机制，而抗体滴度升高和高丙种球蛋白血症反映了E.狗对攻击反应的差异可能反映了患有严重疾病的犬与未患严重疾病的犬之间的潜在免疫学差异。
For further elucidation of the pathogenesis of tropical canine pancytopenia (TCP), 14 German shepherd dogs were evaluated following infection withEhrlichia canis, therapy with tetracycline, and challenge inoculation. Nine dogs developed severe chronic TCP, characterized by severe pancytopenia, hemorrhage, and secondary bacterial infection. In all dogs antibody titers increased for more than 80 days after infection, and all dogs developed hypergammaglobulinemia. Prolonged and incomplete hematologic recovery followed termination of infection by tetracycline therapy in dogs with severe chronic disease. After treatment levels of serum γ-globulin returned to normal. A second inoculation of treated dogs withE. canisresulted in reinfection and hypergammaglobulinemia, but with variable increases in serum antibody. Results indicate that aplastic anemia may be important in the pathogenesis of severe chronic TCP, and that increasing antibody titers and hypergammaglobulinemia reflect persistent infection withE. canis. Differences in response to challenge may reflect underlying immunologic differences between dogs with severe disease and those that do not become seriously ill.